Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention

被引：11

作者：

Hansen, Anders E. ^{[1
]}

Henriksen, Jonas R. ^{[1
]}

Jolck, Rasmus, I ^{[1
]}

Fliedner, Frederikke P. ^{[2
,3
,4
]}

Bruun, Linda M. ^{[1
]}

Scherman, Jonas ^{[5
]}

Jensen, Andreas, I ^{[6
]}

Rosenschold, Per Munck Af ^{[5
]}

Moorman, Lilah ^{[7
]}

Kurbegovic, Sorel ^{[2
,3
,4
]}

de Blanck, Steen R. ^{[8
]}

Larsen, Klaus R. ^{[9
]}

Clementsen, Paul F. ^{[10
,11
]}

Christensen, Anders N. ^{[12
]}

Clausen, Mads H. ^{[13
]}

Wang, Wenbo ^{[1
]}

Kempen, Paul ^{[1
]}

Christensen, Merete ^{[13
]}

Viby, Niels-Erik ^{[13
]}

Persson, Gitte ^{[14
]}

Larsen, Rasmus ^{[12
]}

Conradsen, Knut ^{[12
]}

McEvoy, Fintan J. ^{[7
]}

Kjaer, Andreas ^{[2
,3
,4
]}

Eriksen, Thomas ^{[7
]}

Andresen, Thomas L. ^{[1
]}

机构：

[1] Tech Univ Denmark, Ctr Nanomed & Theranost, Sect Biotherapeut Engn & Drug Targeting, DTU Hlth Technol, DK-2800 Lyngby, Denmark

[2] Copenhagen Univ Hosp, Rigshosp, Dept Biomed Sci, Dept Clin Physiol Nucl Med & PET, DK-2200 Copenhagen, Denmark

[3] Copenhagen Univ Hosp, Rigshosp, Dept Biomed Sci, Cluster Mol Imaging, DK-2200 Copenhagen, Denmark

[4] Univ Copenhagen, DK-2200 Copenhagen, Denmark

[5] Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Radiat Phys, SE-22242 Lund, Sweden

[6] Tech Univ Denmark, Hevesy Lab, DTU Hlth Technol, DK-4000 Roskilde, Denmark

[7] Univ Copenhagen, Dept Vet Clin & Anim Sci, DK-1870 Frederiksberg, Denmark

[8] Copenhagen Univ Hosp, Rigshosp, Dept Oncol, DK-2100 Copenhagen, Denmark

[9] Copenhagen Univ Hosp, Bispebjerg & Frederiksberg Hosp, Dept Resp Med, DK-2400 Copenhagen, Denmark

[10] Zealand Univ Hosp, Copenhagen Acad Med Educ & Simulat CAMES, Dept Internal Med, Roskilde, Denmark

[11] Univ Copenhagen, Dept Clin Med, DK-2100 Copenhagen, Denmark

[12] Tech Univ Denmark, Sect Appl Math & Comp Sci, DTU Compute, DK-2800 Lyngby, Denmark

[13] Copenhagen Univ Hosp, Rigshosp, Dept Cardiothorac Surg, DK-2100 Copenhagen, Denmark

[14] Univ Copenhagen, Herlev Gentofte Hosp, Fac Hlth Sci, Dept Clin Med,Dept Oncol, DK-2200 Copenhagen, Denmark

来源：

SCIENCE ADVANCES | 2020年 / 6卷 / 34期

关键词：

LIQUID FIDUCIAL MARKER; OCCULT LESION LOCALIZATION; PERCUTANEOUSLY IMPLANTED MARKERS; GUIDED RADIOTHERAPY; RADIOGUIDED SURGERY; LUNG; VISIBILITY; CANCER; QUANTIFICATION; STABILITY;

D O I：

10.1126/sciadv.abb5353

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel). The liquid state of these markers allows for high-precision placement under image guidance using thin needles. Based on step-by-step modifications, the image features and mechanical properties of markers can be optimized to bridge diagnostic imaging and specific therapeutic interventions. The performance of Carbo-gel is demonstrated for markers that (i) have radiographic, magnetic resonance, and ultrasound visibility; (ii) are palpable and visible; and (iii) are localizable by near-infrared fluorescence and radio guidance. The study demonstrates encouraging proof of concept for the liquid marker system as a well-tolerated multimodal imaging marker that can improve image-guided radiotherapy and surgical interventions, including robotic surgery.

引用

页数：12

共 41 条

[1] Lung cancer surgery: an up to date [J].