Inhibitors of HIV-1 protease by using in situ click chemistry

被引：489
作者：
Whiting, M
Muldoon, J
Lin, YC
Silverman, SM
Lindstrom, W
Olson, AJ
Kolb, HC
Finn, MG
Sharpless, KB
Elder, JH
Fokin, VV
机构：
[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 09期
关键词：
click chemistry; drug design; HIV-1; protease; inhibitors; triazoles;
D O I：
10.1002/anie.200502161
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Twice poor equals potent: HIV-1 Protease assembles its own potent inhibitor through formation of the triazole linkage from azide- and alkyne-containing fragments that are themselves poor binders. © 2006 Wiley-VCH Verlag GmbH S. Co. KGaA.
引用
收藏
页码：1435 / 1439
页数：5
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