Hepatotoxicity with Combination of Vemurafenib and Ipilimumab

被引:579
作者
Ribas, Antoni [1 ]
Hodi, F. Stephen [2 ]
Callahan, Margaret [3 ]
Konto, Cyril [4 ]
Wolchok, Jedd [3 ]
机构
[1] Univ Calif Los Angeles, Los Angeles, CA 90024 USA
[2] Dana Farber Canc Inst, Boston, MA 02115 USA
[3] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
[4] Bristol Myers Squibb Co, Wallingford, CT 06492 USA
关键词
ANTITUMOR-ACTIVITY; IMMUNOTHERAPY; MELANOMA;
D O I
10.1056/NEJMc1302338
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1365 / 1366
页数:3
相关论文
共 5 条
[1]   Selective BRAFV600E Inhibition Enhances T-Cell Recognition of Melanoma without Affecting Lymphocyte Function [J].
Boni, Andrea ;
Cogdill, Alexandria P. ;
Dang, Ping ;
Udayakumar, Durga ;
Njauw, Ching-Ni Jenny ;
Sloss, Callum M. ;
Ferrone, Cristina R. ;
Flaherty, Keith T. ;
Lawrence, Donald P. ;
Fisher, David E. ;
Tsao, Hensin ;
Wargo, Jennifer A. .
CANCER RESEARCH, 2010, 70 (13) :5213-5219
[2]   The Oncogenic BRAF Kinase Inhibitor PLX4032/RG7204 Does Not Affect the Viability or Function of Human Lymphocytes across a Wide Range of Concentrations [J].
Comin-Anduix, Begona ;
Chodon, Thinle ;
Sazegar, Hooman ;
Matsunaga, Douglas ;
Mock, Stephen ;
Jalil, Jason ;
Escuin-Ordinas, Helena ;
Chmielowski, Bartosz ;
Koya, Richard C. ;
Ribas, Antoni .
CLINICAL CANCER RESEARCH, 2010, 16 (24) :6040-6048
[3]   BRAF Inhibitor Vemurafenib Improves the Antitumor Activity of Adoptive Cell Immunotherapy [J].
Koya, Richard C. ;
Mok, Stephen ;
Otte, Nicholas ;
Blacketor, Kevin J. ;
Comin-Anduix, Begonya ;
Tumeh, Paul C. ;
Minasyan, Aspram ;
Graham, Nicholas A. ;
Graeber, Thomas G. ;
Chodon, Thinle ;
Ribas, Antoni .
CANCER RESEARCH, 2012, 72 (16) :3928-3937
[4]   BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice [J].
Liu, Chengwen ;
Peng, Weiyi ;
Xu, Chunyu ;
Lou, Yanyan ;
Zhang, Minying ;
Wargo, Jennifer A. ;
Chen, Jie Qing ;
Li, Haiyan S. ;
Watowich, Stephanie S. ;
Yang, Yan ;
Frederick, Dennie Tompers ;
Cooper, Zachary A. ;
Mbofung, Rina M. ;
Whittington, Mayra ;
Flaherty, Keith T. ;
Woodman, Scott E. ;
Davies, Michael A. ;
Radvanyi, Laszlo G. ;
Overwijk, Willem W. ;
Lizee, Gregory ;
Hwu, Patrick .
CLINICAL CANCER RESEARCH, 2013, 19 (02) :393-403
[5]   Targeting Oncogenic Drivers and the Immune System in Melanoma [J].
McArthur, Grant A. ;
Ribas, Antoni .
JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (04) :499-506