Transplantation of bone marrow mononuclear cells does not affect postinfarction electrical remodeling of the heart

被引：0
|
作者：
Maslov, L. N. [1 ]
Shakhov, V. P. [1 ]
Krylatov, A. V. [1 ]
Platonov, A. A. [1 ]
机构：
[1] Russian Acad Med Sci, Tomsk Res Ctr, Inst Cardiol, Siberian Div, Moscow 109801, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2008年 / 145卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
stem cells; postinfarction remodeling of the heart; regeneration;
D O I：
10.1007/s10517-008-0029-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of allotransplantation of bone marrow mononuclear cells on postinfarction remodeling of the heart in rats. The cells were transplanted into the periinfarction zone of the heart. The transplantation was performed on day 9 after coronary occlusion. It was found that on day 45 after coronary occlusion myocardial hypertrophy developed, ventricular fibrillation threshold decreased, but myocardial contractility remained within the normal. Allotransplantation of bone marrow mononuclear cells had no effect on myocardial hypertrophy and did not prevent the development of electrical instability of the heart.
引用
收藏
页码：129 / 132
页数：4
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