Novozyme 435-catalyzed efficient acylation of 3-n-butylphthalide in organic medium

被引：4

作者：

He, Laping ^{[1
]}

Sun, Jiong ^{[1
]}

Xu, Yan ^{[1
]}

Sun, Zhihao ^{[1
]}

Zheng, Changge ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Biotechnol, Minist Educ, Key Lab Ind Biotechnol, Wuxi 214122, Jiangsu Prov, Peoples R China

来源：

PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY | 2008年 / 38卷 / 04期

关键词：

acylation; 3-n-butylphthalide; novozyme; 435; organic solvent; salt hydrate; water activity;

D O I：

10.1080/10826060802325501

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Novozyme 435 could catalyze efficient acylation of 3-n-butylphthalide in organic medium. The conversion of 3-n-butylphthalide increased with the increase of hydrophobicity of solvent below that of hexane. The more available solvent was hexane. Salt hydride could control fixed water activity. The optimum water activity was 0.62. And the optimum of reaction time, velocity of agitation, dosage of Novozyme 435 and acetic anhydride to 3-n-butylphtrhalide molar ratio were 48 hours, 150rpm, 8mg/mL and 8:1, respectively. The conversion of 48.9% could be obtained at a water activity of 0.62 in hexane. Furthermore, Novozyme 435 had an enantioselective acylation of racemic 3-n-butylphthalide by original analysis.

引用

页码：376 / 388

页数：13

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