An Integrated Synthesis-Purification System to Accelerate the Generation of Compounds in Pharmaceutical Discovery

被引：25

作者：

Hochlowski, Jill E. ^{[1
]}

Searle, Philip A. ^{[2
]}

Tu, Noah P. ^{[1
]}

Pan, Jeffrey Y. ^{[3
]}

Spanton, Stephen G. ^{[1
]}

Djuric, Stevan W. ^{[2
]}

机构：

[1] Abbott Labs, Global Res & Dev, Adv Technol, Struct Chem, Abbott Pk, IL 60064 USA

[2] Abbott Labs, Global Res & Dev, Adv Technol, Med Chem Technol, Abbott Pk, IL 60064 USA

[3] Abbott Labs, Global Res & Dev, Adv Technol, Automat Engn, Abbott Pk, IL 60064 USA

来源：

JOURNAL OF FLOW CHEMISTRY | 2011年 / 1卷 / 02期

关键词：

flow synthesis; high-throughput organic synthesis; high-throughput purification; segmented flow; meso-flow;

D O I：

10.1556/jfchem.2011.00013

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report herein a high-throughput integrated synthesis-purification platform termed SWIFT (synthesis with integrated-flow technology) and processes that accelerate the rate at which validated small-molecule organic compounds are generated. A segmented-flow synthesizer was integrated to a preparative HPLC-MS, where each reaction product was purified immediately upon reaction completion. Further, automated structure-validation processes accelerate the rate at which drug discovery candidates are available for biological screening.

引用

页码：56 / 61

页数：6

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