Complement and its role in protection and pathogenesis of flavivirus infections

被引：48
作者：
Avirutnan, Panisadee [1 ,4 ]
Mehlhop, Erin [2 ]
Diamond, Michael S. [1 ,2 ,3 ]
机构：
[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
[4] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Res & Dev,Med Mol Biol Unit, Bangkok 10700, Thailand
来源：
VACCINE | 2008年 / 26卷
关键词：
Virus; Innate Immunity; Dengue; West Nile; Immune Evasion;
D O I：
10.1016/j.vaccine.2008.11.061
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The complement system is a family of serum and cell surface proteins that recognize pathogen-associated molecular patterns, altered-self ligands, and immune complexes. Activation of the complement cascade triggers several antiviral functions including pathogen opsonization and/or lysis, and priming of adaptive immune responses. In this review. we will examine the role of complement activation in protection and/or pathogenesis against infection by Flaviviruses, with an emphasis on experiments with West Nile and Dengue viruses. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：I100 / I107
页数：8
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