Introduction: The effectiveness of sleeve gastrectomy has been confirmed in many studies. The impact of individual factors on the parameters of weight loss is still not clear. Aim: To identify important factors affecting the parameters of weight loss after sleeve gastrectomy. Material and methods: The impact of prognostic factors and postoperative care components on body mass index (BMI) and percentage excess weight loss (%EWL) was assessed in a group of 100 consecutive patients who underwent laparoscopic sleeve gastrectomy. Results: The baseline BMI and body mass in patients with BMI < 30 kg/m(2) and BMI 30 kg/m(2) 12 months after surgery were, respectively, 39.7 +/- 3.2 vs. 45.9 +/- 4.6 kg/m(2), p <0.0001, and 114.4 +/- 16.8 vs. 130.3 +/- 18.5 kg, p <0.0001. In the group with EWL <50%, the average age was 47.1 +/- 7.7 vs. 40.6 +/- 10.8 in the group with EWL 50%, p = 0.0025. In the group of patients with preoperative weight loss, %EWL was 61.4 +/- 17.2 vs. 53.3 +/- 19.3% in the group with no weight loss, p = 0.0496. Body mass index of the patients who started physical activities was 30.6 +/- 4.2 kg/m(2) vs. 34.0 +/- 5.6 kg/m(2) in the patients with no physical activity, p = 0.0013, and %EWL was 63.4 +/- 14.6 vs. 47.0 +/- 19.9%, p <0.0001, respectively. In the case of patients regularly consulted by a dietician BMI was 30.6 +/- 4.2 kg/m(2) vs. 35.1 +/- 5.5 kg/m(2) in the group without systematic consultations, p <0.0001, and %EWL was 63.1 +/- 15.1% vs. 42.3 +/- 18.2%, p <0.0001. Conclusions: Lower baseline body weight parameters, younger age, preoperative weight loss, starting systematic physical activities and constant care of a dietician were conducive to achieving better results of surgery, as assessed on the basis of changes in BMI and %EWL.