Discovery of Levesquamide B through Global Natural Product Social Molecular Networking

被引：4

作者：

LeClair, Mary M. ^{[1
]}

Maw, Zacharie A. ^{[2
]}

Grunwald, Alyssa L. ^{[3
]}

Kelly, Joshua R. ^{[3
]}

Haltli, Bradley A. ^{[2
,3
]}

Kerr, Russell G. ^{[1
,2
,3
]}

Cartmell, Christopher ^{[1
,4
]}

机构：

[1] Univ Prince Edward Isl, Dept Chem, 550 Univ Ave, Charlottetown, PE C1A 4P3, Canada

[2] Atlantic Vet Coll, Dept Biomed Sci, 550 Univ Ave, Charlottetown, PE C1A 4P3, Canada

[3] Nautilus Biosci Croda, 550 Univ Ave, Charlottetown, PE C1A 4P3, Canada

[4] Northeastern Univ, Antimicrobial Discovery Ctr, Dept Biol, Boston, MA 02115 USA

来源：

MOLECULES | 2022年 / 27卷 / 22期

基金：

加拿大创新基金会;

关键词：

levesquamide; GNPS; marine natural product; Streptomyces; MASS-SPECTROMETRY; DRUG DISCOVERY; POLYKETIDE;

D O I：

10.3390/molecules27227794

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Levesquamide A is an isothiazolinone-containing anti-tubercular natural product isolated from Streptomyces sp. RKND-216. Through the use of Global Natural Product Social Molecular Networking (GNPS), additional members of the levesquamide family were identified (B-G). Levesquamide B is a glycosylated analogue, isolated and structurally elucidated via spectroscopical techniques along with the putative structures of levesquamide C and D. For masses relating to the additional three levesquamides (E-G), their complete structures remain ambiguous.

引用

页数：10