Discovery of Levesquamide B through Global Natural Product Social Molecular Networking

被引：4
作者：
LeClair, Mary M. [1 ]
Maw, Zacharie A. [2 ]
Grunwald, Alyssa L. [3 ]
Kelly, Joshua R. [3 ]
Haltli, Bradley A. [2 ,3 ]
Kerr, Russell G. [1 ,2 ,3 ]
Cartmell, Christopher [1 ,4 ]
机构：
[1] Univ Prince Edward Isl, Dept Chem, 550 Univ Ave, Charlottetown, PE C1A 4P3, Canada
[2] Atlantic Vet Coll, Dept Biomed Sci, 550 Univ Ave, Charlottetown, PE C1A 4P3, Canada
[3] Nautilus Biosci Croda, 550 Univ Ave, Charlottetown, PE C1A 4P3, Canada
[4] Northeastern Univ, Antimicrobial Discovery Ctr, Dept Biol, Boston, MA 02115 USA
来源：
MOLECULES | 2022年 / 27卷 / 22期
基金：
加拿大创新基金会;
关键词：
levesquamide; GNPS; marine natural product; Streptomyces; MASS-SPECTROMETRY; DRUG DISCOVERY; POLYKETIDE;
D O I：
10.3390/molecules27227794
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Levesquamide A is an isothiazolinone-containing anti-tubercular natural product isolated from Streptomyces sp. RKND-216. Through the use of Global Natural Product Social Molecular Networking (GNPS), additional members of the levesquamide family were identified (B-G). Levesquamide B is a glycosylated analogue, isolated and structurally elucidated via spectroscopical techniques along with the putative structures of levesquamide C and D. For masses relating to the additional three levesquamides (E-G), their complete structures remain ambiguous.
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页数：10
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