Modification of polysulfone with phospholipid polymer for improvement of the blood compatibility. Part 1. Surface characterization

被引：137
作者：
Ishihara, K
Fukumoto, K
Iwasaki, Y
Nakabayashi, N
机构：
[1] Univ Tokyo, Grad Sch Engn, Dept Mat Sci, Bunkyo Ku, Tokyo 1138656, Japan
[2] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan
来源：
BIOMATERIALS | 1999年 / 20卷 / 17期
关键词：
polysulfone; phospholipid polymer; blood compatibility; blending; surface modification; fibrinogen adsorption;
D O I：
10.1016/S0142-9612(99)00052-6
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
To improve the surface blood compatibility of polysulfone (PSf) membranes, we prepared novel polymeric additives which have suitable blood compatibility. They were polymers with a phosphorylcholine group, a 2-methacryloyloxyethyl phosphorylcholine (MPC) unit. The MPC polymer could be blended with polysulfone by a solvent evaporation method during membrane processing, and a transparent membrane could be obtained. The mechanical properties of the blend membrane were similar to that of the original PSf membrane. Surface analysis of the blend membrane by X-ray photoelectron spectroscopy and dynamic contact angle measurement revealed that the MPC unit in the polymeric additive was concentrated on the surface of the membrane. The blend membrane significantly reduced plasma protein adsorption compared with that of the PSf membrane. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1545 / 1551
页数：7
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