Self-assembly of small-molecule fumaramides allows transmembrane chloride channel formation

被引：34
作者：
Roy, Arundhati [1 ]
Gautam, Amitosh [1 ,2 ]
Malla, Javid Ahmad [1 ]
Sarkar, Sohini [1 ]
Mukherjee, Arnab [1 ]
Talukdar, Pinaki [1 ]
机构：
[1] Indian Inst Sci Educ & Res Pune, Dept Chem, Pune 411008, Maharashtra, India
[2] Inst Bioengn & Nanotechnol, 31 Bioplis Way, Singapore 138669, Singapore
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 16期
关键词：
SYNTHETIC ION CHANNELS; ARTIFICIAL CHANNELS; TRANSPORT ACTIVITY; ANION TRANSPORT; MEMBRANES; PEPTIDE; FOLDAMERS; CHEMISTRY; MACHINES; SYSTEMS;
D O I：
10.1039/c7cc08693h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This study reports the formation of self-assembled transmembrane anion channels by small-molecule fumaramides. Such artificial ion channel formation was confirmed by ion transport across liposomes and by planar bilayer conductance measurements. The geometry-optimized model of the channel and Cl- ion selectivity within the channel lumen was also illustrated.
引用
收藏
页码：2024 / 2027
页数：4
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