Can NK cells be a therapeutic target in human cancer?

被引：24
作者：
Chan, Christopher J. [1 ]
Andrews, Daniel M. [1 ]
Smyth, Mark J. [1 ]
机构：
[1] Peter MacCallum Canc Ctr, East Melbourne, Australia
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2008年 / 38卷 / 11期
基金：
英国医学研究理事会;
关键词：
Cancer; Immunosurveillance; NK cells; Therapy;
D O I：
10.1002/eji.200838764
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Our current knowledge of NK-cell recognition and effector function suggests that it will be possible to design various new NK-cell-based immunotherapies against human cancer. The application of NK cells is already showing promise using HLA-mismatched haematopoietic stem cell transplantation for treatment of haematological malignancies. A better understanding of NK-cell heterogeneity and function will only broaden the applications for human cancer. Here we review the key developments that will propel this field.
引用
收藏
页码：2964 / 2968
页数：5
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