The hematopoietic system: a new niche for the renin-angiotensin system

被引：48
作者：
Hubert, C
Savary, K
Gasc, JM
Corvol, P
机构：
[1] Coll France, INSERM, U36, F-75005 Paris, France
[2] INSERM, Vasc Pathol & Renal Endocrinol Unit, F-75654 Paris 13, France
来源：
NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE | 2006年 / 3卷 / 02期
关键词：
anemia; angiotensin-II-receptor antagonist; angiotensin-converting-enzyme inhibitors; definitive hematopoiesis; primitive hematopoiesis;
D O I：
10.1038/ncpcardio0449
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The restricted to the cardiovascular system. It now appears that this system also has important functions in other tissues. Hematopoiesis can be affected by inhibitors of the renin system in patients and in various experimental models. The renin system, particularly angiotensin II, has a role in different stages of hematopoiesis, notably during the first wave in the chick embryo (primitive hematopoiesis) and in the human adult (definitive hematopoiesis). In addition, the renin-angiotensin system in mice is involved in reconstitutive hematopoiesis following experimental irradiation; inhibition of this system improved the hematopoietic recovery in this situation. The clinical relevance and therapeutic applications of these findings offer a new area of clinical research. In this article, we review the evidence for a role for the renin system in the control of hematopoiesis at its different stages.
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收藏
页码：80 / 85
页数：6
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