Transgenic Mouse Models of Tumor Virus Action

被引：27
|
作者：
Lambert, Paul F. [1 ]
机构：
[1] Univ Wisconsin, McArdle Lab Canc Res, Dept Oncol, Sch Med & Publ Hlth, Madison, WI 53705 USA
来源：
ANNUAL REVIEW OF VIROLOGY, VOL 3 | 2016年 / 3卷
基金：
美国国家卫生研究院;
关键词：
HPV; EBV; KSHV; MCPyV; GEM; transgenic; cancer; in vivo; EPSTEIN-BARR-VIRUS; HUMAN-PAPILLOMAVIRUS TYPE-16; MEMBRANE-PROTEIN; 2A; CERVICAL-CARCINOMA CELLS; ESTROGEN-RECEPTOR-ALPHA; FANCONI-ANEMIA PATIENTS; DNA-DAMAGE RESPONSE; NF-KAPPA-B; IN-VIVO; KAPOSIS-SARCOMA;
D O I：
10.1146/annurev-virology-100114-054908
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Genetically engineered mice (GEMs) have provided valuable insights into the carcinogenic properties of various human tumor viruses, which, in aggregate, are etiologically associated with over 15% of all human cancers. This review provides an overview of seminal discoveries made through the use of GEM models for human DNA tumor viruses. Emphasis is placed on the discoveries made in the study of human papillomaviruses, Merkel cell carcinoma-associated polyomavirus, Epstein-Barr virus, and Kaposi's sarcoma-associated herpesvirus, because GEMs have contributed extensively to our understanding of how these DNA tumor viruses directly contribute to human cancers.
引用
收藏
页码：473 / 489
页数：17
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