Transgenic Mouse Models of Tumor Virus Action

被引:27
|
作者
Lambert, Paul F. [1 ]
机构
[1] Univ Wisconsin, McArdle Lab Canc Res, Dept Oncol, Sch Med & Publ Hlth, Madison, WI 53705 USA
来源
ANNUAL REVIEW OF VIROLOGY, VOL 3 | 2016年 / 3卷
基金
美国国家卫生研究院;
关键词
HPV; EBV; KSHV; MCPyV; GEM; transgenic; cancer; in vivo; EPSTEIN-BARR-VIRUS; HUMAN-PAPILLOMAVIRUS TYPE-16; MEMBRANE-PROTEIN; 2A; CERVICAL-CARCINOMA CELLS; ESTROGEN-RECEPTOR-ALPHA; FANCONI-ANEMIA PATIENTS; DNA-DAMAGE RESPONSE; NF-KAPPA-B; IN-VIVO; KAPOSIS-SARCOMA;
D O I
10.1146/annurev-virology-100114-054908
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Genetically engineered mice (GEMs) have provided valuable insights into the carcinogenic properties of various human tumor viruses, which, in aggregate, are etiologically associated with over 15% of all human cancers. This review provides an overview of seminal discoveries made through the use of GEM models for human DNA tumor viruses. Emphasis is placed on the discoveries made in the study of human papillomaviruses, Merkel cell carcinoma-associated polyomavirus, Epstein-Barr virus, and Kaposi's sarcoma-associated herpesvirus, because GEMs have contributed extensively to our understanding of how these DNA tumor viruses directly contribute to human cancers.
引用
收藏
页码:473 / 489
页数:17
相关论文
共 50 条
  • [1] Transgenic mouse models for tumor suppressor genes
    Palapattu, GS
    Bao, SD
    Kumar, TR
    Matzuk, MM
    CANCER DETECTION AND PREVENTION, 1998, 22 (01): : 75 - 86
  • [2] TRANSGENIC MOUSE MODELS FOR TUMOR-SUPPRESSOR GENES
    KUMAR, TR
    DONEHOWER, LA
    BRADLEY, A
    MATZUK, MM
    JOURNAL OF INTERNAL MEDICINE, 1995, 238 (03) : 233 - 238
  • [3] Thyroid hormone action: Insight from transgenic mouse models
    Wondisford, FE
    JOURNAL OF INVESTIGATIVE MEDICINE, 2003, 51 (04) : 215 - 220
  • [4] ONCOGENES AND TUMOR SUPPRESSOR GENES IN TRANSGENIC MOUSE MODELS OF NEOPLASIA
    FOWLIS, DJ
    BALMAIN, A
    EUROPEAN JOURNAL OF CANCER, 1993, 29A (04) : 638 - 645
  • [5] Transgenic mouse models
    Sedlak, BJ
    GENETIC ENGINEERING NEWS, 1999, 19 (19): : 14 - +
  • [6] ACTION OF COXSACKIE VIRUS ON AN EXPERIMENTAL MOUSE TUMOR CULTIVATED INVITRO
    DELUSTIG, ES
    ANATOMICAL RECORD, 1954, 118 (02): : 448 - 448
  • [7] The mouse mammary tumor virus mediates the antineoplastic action of decitabine
    Light, Sarah
    Montazer, Maziar
    Wycoff, Cade
    Tuttle, Richard
    Brola, Andrew
    Wycoff, William
    Johnson, Ryan
    Liu, Yingguang
    CANCER RESEARCH, 2024, 84 (07)
  • [8] GLUCOCORTICOID REGULATION OF MOUSE MAMMARY-TUMOR VIRUS SEQUENCES IN TRANSGENIC MICE
    ROSS, SR
    SOLTER, D
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (17) : 5880 - 5884
  • [9] Transgenic mouse models of retinoblastoma
    Chen, Q
    Liang, D
    Chen, L
    Overbeek, PA
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 : U607 - U607
  • [10] Transgenic mouse models for ADHD
    Damiana Leo
    Raul R. Gainetdinov
    Cell and Tissue Research, 2013, 354 : 259 - 271