Tamoxifen inhibits prolactin signal transduction in ER - NOG-8 mammary epithelial cells

被引：7
|
作者：
Das, R [1 ]
Vonderhaar, BK [1 ]
机构：
[1] NCI,TUMOR IMMUNOL & BIOL LAB,BETHESDA,MD 20892
来源：
CANCER LETTERS | 1997年 / 116卷 / 01期
关键词：
tamoxifen; antilactogen; prolactin;
D O I：
10.1016/S0304-3835(97)04750-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tamoxifen (TAM), an antiestrogen, also acts as an antilactogen in mammary cells. In the present study we analyze the effect of TAM on the signal transduction pathway for prolactin (Prl). TAM bound specifically to NOG-8, an estrogen receptor-negative mammary cell line. Within 5 min of Prl treatment, raf-l, MEK and MAP kinase were induced 2-3-fold over the control level. TAM completely inhibited this Prl-induced activation of kinases as well as Prl binding and cell growth. These results indicate the potential role of TAM as an antilactogen in Prl responsive systems. Published by Elsevier Science Ireland Ltd.
引用
收藏
页码：41 / 46
页数：6
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