Role of mixed Th1 and Th2 serum cytokines on pathogenesis and prognosis of hantavirus pulmonary syndrome

被引：47

作者：

Borges, Alessandra Abel ^{[2
,3
]}

Campos, Gelse Mazzoni ^{[2
]}

Moreli, Marcos Lazaro ^{[2
]}

Moro Souza, Ricardo Luiz ^{[2
]}

Saggioro, Fabiano Pinto ^{[1
]}

Figueiredo, Glauciane Garcia ^{[2
]}

Livonesi, Marcia Cristina ^{[2
]}

Moraes Figueiredo, Luiz Tadeu ^{[2
]}

机构：

[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pathol, BR-14049900 Ribeirao Preto, SP, Brazil

[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Virol Res Ctr, BR-14049900 Ribeirao Preto, SP, Brazil

[3] Univ S Santa Catarina UNISUL, Sch Med, Virol Res Unit, BR-88704900 Tubarao, Santa Catarina, Brazil

来源：

MICROBES AND INFECTION | 2008年 / 10卷 / 10-11期

基金：

巴西圣保罗研究基金会;

关键词：

Hantavirus; Pulmonary syndrome; Cytokines; Pathogenesis; Immune response;

D O I：

10.1016/j.micinf.2008.06.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The hantavirus pulmonary syndrome (HPS) is an emerging syndrome in the Americas. The disease results from intense immune activation and changes in vascular permeability. The aim of this study was to determine the profile of serum cytokines in HPS patients looking for correlation with the clinical parameters, severity and outcome of illness. Studying 21 HPS patients, we found that IL-6 may have an important role in the pathogenesis of HPS, being associated with fatal outcome. Our results also support a mixed Th1/Th2 immune response during the course of HPS and that the magnitude of Th1 response effector cytokines is correlated to HPS severity. The decreased levels of TGF-beta observed in HPS patients suggest that immunoregulatory activity could be damaged in these patients. (c) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：1150 / 1157

页数：8

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