Role of mixed Th1 and Th2 serum cytokines on pathogenesis and prognosis of hantavirus pulmonary syndrome

被引：47

作者：

Borges, Alessandra Abel ^{[2
,3
]}

Campos, Gelse Mazzoni ^{[2
]}

Moreli, Marcos Lazaro ^{[2
]}

Moro Souza, Ricardo Luiz ^{[2
]}

Saggioro, Fabiano Pinto ^{[1
]}

Figueiredo, Glauciane Garcia ^{[2
]}

Livonesi, Marcia Cristina ^{[2
]}

Moraes Figueiredo, Luiz Tadeu ^{[2
]}

机构：

[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pathol, BR-14049900 Ribeirao Preto, SP, Brazil

[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Virol Res Ctr, BR-14049900 Ribeirao Preto, SP, Brazil

[3] Univ S Santa Catarina UNISUL, Sch Med, Virol Res Unit, BR-88704900 Tubarao, Santa Catarina, Brazil

来源：

MICROBES AND INFECTION | 2008年 / 10卷 / 10-11期

基金：

巴西圣保罗研究基金会;

关键词：

Hantavirus; Pulmonary syndrome; Cytokines; Pathogenesis; Immune response;

D O I：

10.1016/j.micinf.2008.06.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The hantavirus pulmonary syndrome (HPS) is an emerging syndrome in the Americas. The disease results from intense immune activation and changes in vascular permeability. The aim of this study was to determine the profile of serum cytokines in HPS patients looking for correlation with the clinical parameters, severity and outcome of illness. Studying 21 HPS patients, we found that IL-6 may have an important role in the pathogenesis of HPS, being associated with fatal outcome. Our results also support a mixed Th1/Th2 immune response during the course of HPS and that the magnitude of Th1 response effector cytokines is correlated to HPS severity. The decreased levels of TGF-beta observed in HPS patients suggest that immunoregulatory activity could be damaged in these patients. (c) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：1150 / 1157

页数：8

共 50 条

[1] Role of Th1/Th2 cytokines in serum on the pathogenesis of chronic hepatitis C and the outcome of interferon therapy
Zhang, L.
Hao, C. Q.
Miao, L.
Dou, X. G.
GENETICS AND MOLECULAR RESEARCH, 2014, 13 (04) : 9747 - 9755
[2] Th1, Th2 and Th3 cytokines in the pathogenesis of bullous pemphigoid
Giomi, B
Caproni, M
Calzolari, A
Bianchi, B
Fabbri, P
JOURNAL OF DERMATOLOGICAL SCIENCE, 2002, 30 (02) : 116 - 128
[3] Th1/Th2 cytokines in psoriasis
Jadali, Z.
Izad, M.
Eslami, M. B.
Mansouri, P.
Safari, R.
Bayatian, P.
Mirshafiey, A.
Nodeh, A. R. Salehi
IRANIAN JOURNAL OF PUBLIC HEALTH, 2007, 36 (02): : 87 - 91
[4] The balance of Th1/Th2 cytokines in rheumatoid arthritis
Schulze-Koops, H
Kalden, JK
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY, 2001, 15 (05): : 677 - 691
[5] Role of Th1/Th2 cells and related cytokines in autoimmune hepatitis
Behfarjam, Farinaz
Sanati, Mohammad Hossein
Nasseri-Moghaddam, Siavash
Ataei, Mitra
Nikfam, Sepideh
Jadali, Zohreh
TURKISH JOURNAL OF GASTROENTEROLOGY, 2017, 28 (02) : 110 - 114
[6] The role of the Th1 and Th2 dichotomy in the pathogenesis of juvenile chronic arthritis
Miossec, P
REVUE DU RHUMATISME, 1997, 64 (10): : S138 - S139
[7] Coexisting Th1 and Th2 cytokines in patients with collagenous gastritis and implications for its pathogenesis
Liu, Qingqing
Wang, Yanping
Harpaz, Noam
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2024, 78 (02) : 231 - 240
[8] Cytokines, Th1/Th2 profile and successful pregnancy?
Chaouat, G
REVUE FRANCAISE D ALLERGOLOGIE ET D IMMUNOLOGIE CLINIQUE, 1999, 39 (08): : 633 - 642
[9] Th1/Th2 cytokines in the central nervous system
Sredni-Kenigsbuch, D
INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2002, 112 (06) : 665 - 703
[10] The role of immune response in the pathogenesis of idiopathic pulmonary fibrosis: far beyond the Th1/Th2 imbalance
Spagnolo, Paolo
Tonelli, Roberto
Samarelli, Anna Valeria
Castelli, Gioele
Cocconcelli, Elisabetta
Petrarulo, Simone
Cerri, Stefania
Bernardinello, Nicol
Clini, Enrico
Saetta, Marina
Balestro, Elisabetta
EXPERT OPINION ON THERAPEUTIC TARGETS, 2022, 26 (07) : 617 - 631

← 1 2 3 4 5 →