Effect of Carnosine and Related Compounds on Proliferation of Cultured Rat Pheochromocytoma PC-12 Cells

被引：8
|
作者：
Rybakova, Yu. S. [1 ]
Boldyrev, A. A. [1 ]
机构：
[1] Russian Acad Med Sci, Res Ctr Neurol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 154卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
cell cycle; proliferation; carnosine; anserine; acetylcarnosine; antioxidants; HUMAN-DIPLOID FIBROBLASTS; GROWTH;
D O I：
10.1007/s10517-012-1894-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The study was undertaken to determine the mechanism of carnosine effect on cell proliferation. We studied the effect of carnosine and its derivatives on cell cycle progression in cultured rat pheochromocytoma cells (PC-12). It was found that 48-h incubation of PC-12 cells with carnosine in concentrations of 10-50 mM led to deceleration of cell proliferation, reduction of G0/G1 peak, and accumulation of S- and G2/M-phase cells. Methylation of the carnosine molecule by 1N-position of the imidazole ring potentiated its effect on cell proliferation. Acetylation of the carnosine molecule by free beta-amino group attenuated its effect.
引用
收藏
页码：136 / 140
页数：5
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