The Involvement of Microglial Cells in Japanese Encephalitis Infections

被引：30
作者：
Thongtan, Thananya [2 ]
Thepparit, Chutima [1 ]
Smith, Duncan R. [1 ,3 ]
机构：
[1] Mahidol Univ, Inst Mol Biosci, Mol Pathol Lab, Nakhon Pathom 73170, Thailand
[2] Chulalongkorn Univ, Fac Med, Dept Biochem, Bangkok 10330, Thailand
[3] Mahidol Univ, Ctr Emerging & Neglected Infect Dis, Nakhon Pathom 73170, Thailand
来源：
CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2012年
关键词：
BLOOD-BRAIN-BARRIER; VIRUS INFECTION; NEURONAL DEATH; NEUROBLASTOMA-CELLS; ACTIVATED MICROGLIA; CEREBROSPINAL-FLUID; GLIAL ACTIVATION; GLUTAMATE UPTAKE; MOUSE; MINOCYCLINE;
D O I：
10.1155/2012/890586
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases admitted to hospital die and 50% of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection.
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页数：7
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