The Involvement of Microglial Cells in Japanese Encephalitis Infections

被引：28
作者：
Thongtan, Thananya [2 ]
Thepparit, Chutima [1 ]
Smith, Duncan R. [1 ,3 ]
机构：
[1] Mahidol Univ, Inst Mol Biosci, Mol Pathol Lab, Nakhon Pathom 73170, Thailand
[2] Chulalongkorn Univ, Fac Med, Dept Biochem, Bangkok 10330, Thailand
[3] Mahidol Univ, Ctr Emerging & Neglected Infect Dis, Nakhon Pathom 73170, Thailand
来源：
CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2012年
关键词：
BLOOD-BRAIN-BARRIER; VIRUS INFECTION; NEURONAL DEATH; NEUROBLASTOMA-CELLS; ACTIVATED MICROGLIA; CEREBROSPINAL-FLUID; GLIAL ACTIVATION; GLUTAMATE UPTAKE; MOUSE; MINOCYCLINE;
D O I：
10.1155/2012/890586
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Despite the availability of effective vaccines, Japanese encephalitis virus (JEV) infections remain a leading cause of encephalitis in many Asian countries. The virus is transmitted to humans by Culex mosquitoes, and, while the majority of human infections are asymptomatic, up to 30% of JE cases admitted to hospital die and 50% of the survivors suffer from neurological sequelae. Microglia are brain-resident macrophages that play key roles in both the innate and adaptive immune responses in the CNS and are thus of importance in determining the pathology of encephalitis as a result of JEV infection.
引用
收藏
页数：7
相关论文
共 86 条
  • [1] Inflammatory markers in the patients of Japanese encephalitis
    Babu, GN
    Kalita, J
    Misra, UK
    [J]. NEUROLOGICAL RESEARCH, 2006, 28 (02) : 190 - 192
  • [2] Characteristics of compounds that cross the blood-brain barrier
    Banks, William A.
    [J]. BMC NEUROLOGY, 2009, 9
  • [3] The microglial cell. A historical review
    Barron, KD
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1995, 134 : 57 - 68
  • [4] Transport characteristics of a novel peptide platform for CNS therapeutics
    Bertrand, Yanick
    Currie, Jean-Christophe
    Demeule, Michel
    Regina, Anthony
    Che, Christian
    Abulrob, Abedelnasser
    Fatehi, Dorothy
    Sartelet, Herve
    Gabathuler, Reinhard
    Castaigne, Jean-Paul
    Stanimirovic, Danica
    Beliveau, Richard
    [J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2010, 14 (12) : 2827 - 2839
  • [5] Tumor necrosis factor-α modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis
    Carmen, Jessica
    Rothstein, Jeffrey D.
    Kerr, Douglas A.
    [J]. BRAIN RESEARCH, 2009, 1263 : 143 - 154
  • [6] Chanama S, 2005, JPN J INFECT DIS, V58, P294
  • [7] Flavivirus induces interferon-beta gene expression through a pathway involving RIG-I-dependent IRF-3 and PI3K-dependent NF-κB activation
    Chang, TH
    Liao, CL
    Lin, YL
    [J]. MICROBES AND INFECTION, 2006, 8 (01) : 157 - 171
  • [8] Glutamate released by Japanese encephalitis virus-infected microglia involves TNF-a signaling and contributes to neuronal death
    Chen, Chun-Jung
    Ou, Yen-Chuan
    Chang, Cheng-Yi
    Pan, Hung-Chuan
    Liao, Su-Lan
    Chen, Shih-Yun
    Raung, Shue-Ling
    Lai, Ching-Yi
    [J]. GLIA, 2012, 60 (03) : 487 - 501
  • [9] Glial activation involvement in neuronal death by Japanese encephalitis virus infection
    Chen, Chun-Jung
    Ou, Yen-Chuan
    Lin, Shih-Yi
    Raung, Shue-Ling
    Liao, Su-Lan
    Lai, Ching-Yi
    Chen, Shih-Yun
    Chen, Jian-Hong
    [J]. JOURNAL OF GENERAL VIROLOGY, 2010, 91 : 1028 - 1037
  • [10] Japanese Encephalitis Virus infection induces IL-18 and IL-1β in microglia and astrocytes:: Correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death
    Das, Sulagna
    Mishra, Manoj Kumar
    Ghosh, Joydeep
    Basu, Anirban
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2008, 195 (1-2) : 60 - 72
123456789