Encapsulation of quinine by β-cyclodextrin:: Excellent model for mimicking enzyme-substrate interactions

被引：23

作者：

Fan, Z ^{[1
]}

Diao, CH

Song, HB

Jing, ZL

Yu, M

Chen, X

Guo, MJ

机构：

[1] Tianjin Univ Sci & Technol, Coll Sci, Tianjin 300071, Peoples R China

[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 03期

关键词：

D O I：

10.1021/jo052183j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An inclusion complex formed by β-cyclodextrin and quinine has been investigated in solution and in the solid state, in which the quinoline ring and the aliphatic ring locate in different hydrophobic cavities, respectively. The study on the inclusion geometry and weak interactions shows that the difference in conformation for this complex is a result of three main packing arrangement considerations, which can provide an ideal model mimicking enzyme-substrate interactions. © 2006 American Chemical Society.

引用

页码：1244 / 1246

页数：3

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