Immunotherapy with NK cells: recent developments in gene modification open up new avenues

被引：29
作者：
Reindl, Lisa Marie [1 ,2 ]
Albinger, Nawid [1 ,2 ]
Bexte, Tobias [1 ,2 ]
Mueller, Stephan [1 ,2 ]
Hartmann, Jessica [3 ]
Ullrich, Evelyn [1 ,2 ,4 ]
机构：
[1] Goethe Univ Frankfurt, Childrens Hosp, Frankfurt, Germany
[2] Goethe Univ Frankfurt, Expt Immunol, Frankfurt, Germany
[3] Paul Ehrlich Inst, Div Med Biotechnol, Langen, Germany
[4] Goethe Univ, Frankfurt Canc Inst, Frankfurt, Germany
来源：
ONCOIMMUNOLOGY | 2020年 / 9卷 / 01期
关键词：
CAR; NK cells; NK-92; cells; cell therapy; NATURAL-KILLER-CELL; CHIMERIC ANTIGEN RECEPTOR; T-CELLS; MESSENGER-RNA; NK-92; CELLS; HEMATOPOIETIC-CELLS; CORD BLOOD; IN-VITRO; ADOPTIVE TRANSFER; VIVO EXPANSION;
D O I：
10.1080/2162402X.2020.1777651
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chimeric antigen receptor (CAR)-T cell therapies have achieved remarkable success. However, application-related toxicities, such as cytokine release syndrome or neurotoxicity, moved natural killer (NK) cells into focus as novel players in immunotherapy. CAR-NK cells provide an advantageous dual killing-capacity by CAR-dependent and -independent mechanisms and induce few side effects. While the majority of trials still use CAR-T cells, CAR-NK cell trials are on the rise with 19 ongoing studies worldwide. This review illuminates the current state of research and clinical application of CAR-NK cells, as well as future developmental potential.
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页数：12
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