Chimeric antigen receptor (CAR)-T cell therapies have achieved remarkable success. However, application-related toxicities, such as cytokine release syndrome or neurotoxicity, moved natural killer (NK) cells into focus as novel players in immunotherapy. CAR-NK cells provide an advantageous dual killing-capacity by CAR-dependent and -independent mechanisms and induce few side effects. While the majority of trials still use CAR-T cells, CAR-NK cell trials are on the rise with 19 ongoing studies worldwide. This review illuminates the current state of research and clinical application of CAR-NK cells, as well as future developmental potential.
机构:
Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Boissel, Laurent
Betancur, Monica
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h-index: 0
机构:
Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Betancur, Monica
Lu, Weiquan
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h-index: 0
机构:
Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Tufts Med Ctr, Div Hematol Oncol, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Lu, Weiquan
Wels, Winfried S.
论文数: 0引用数: 0
h-index: 0
机构:
Chemotherapeut Forschungsinst Georg Speyer Haus, Frankfurt, GermanyTufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Wels, Winfried S.
Marino, Teresa
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h-index: 0
机构:
Tufts Med Ctr, Div Maternal Fetal Med, Dept Obstet & Gynecol, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Marino, Teresa
Van Etten, Richard A.
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Tufts Med Ctr, Div Hematol Oncol, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Van Etten, Richard A.
Klingemann, Hans
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h-index: 0
机构:
Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Tufts Med Ctr, Div Hematol Oncol, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
机构:
Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Boissel, Laurent
Betancura, Monica
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Betancura, Monica
Wels, Winfried S.
论文数: 0引用数: 0
h-index: 0
机构:
Chemotherapeut Forschungsinst Georg Speyer Haus, Frankfurt, GermanyTufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Wels, Winfried S.
Tuncer, Hande
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Med Ctr, Div Hematol Oncol, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Tuncer, Hande
Klingemann, Hans
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Tufts Med Ctr, Div Hematol Oncol, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
机构:University of Science and Technology of China,Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences
Min Cheng
Jian Zhang
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h-index: 0
机构:University of Science and Technology of China,Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences
Jian Zhang
Wen Jiang
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h-index: 0
机构:University of Science and Technology of China,Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences
Wen Jiang
Yongyan Chen
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h-index: 0
机构:University of Science and Technology of China,Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences
Yongyan Chen
Zhigang Tian
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h-index: 0
机构:University of Science and Technology of China,Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences
机构:
New York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USANew York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
Chu, Yaya
Hochberg, Jessica
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h-index: 0
机构:
New York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USANew York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
Hochberg, Jessica
Yahr, Ashlin
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h-index: 0
机构:
New York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USANew York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
Yahr, Ashlin
Ayello, Janet
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h-index: 0
机构:
New York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USANew York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
Ayello, Janet
van de Ven, Carmella
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h-index: 0
机构:
New York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USANew York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
van de Ven, Carmella
Barth, Matthew
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h-index: 0
机构:
SUNY Buffalo, Dept Pediat, Buffalo, NY 14260 USANew York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
Barth, Matthew
Czuczman, Myron
论文数: 0引用数: 0
h-index: 0
机构:
Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14263 USA
Roswell Pk Canc Inst, Dept Immunol, Buffalo, NY 14263 USANew York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
Czuczman, Myron
Cairo, Mitchell S.
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
New York Med Coll, Dept Med, Valhalla, NY 10595 USA
New York Med Coll, Dept Pathol, Valhalla, NY 10595 USA
New York Med Coll, Dept Microbiol & Immunol, Valhalla, NY 10595 USA
New York Med Coll, Dept Cell Biol & Anat, Valhalla, NY 10595 USANew York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
机构:
Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Boissel, Laurent
Betancur, Monica
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Betancur, Monica
Lu, Weiquan
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Tufts Med Ctr, Div Hematol Oncol, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Lu, Weiquan
Wels, Winfried S.
论文数: 0引用数: 0
h-index: 0
机构:
Chemotherapeut Forschungsinst Georg Speyer Haus, Frankfurt, GermanyTufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Wels, Winfried S.
Marino, Teresa
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Med Ctr, Div Maternal Fetal Med, Dept Obstet & Gynecol, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Marino, Teresa
Van Etten, Richard A.
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Tufts Med Ctr, Div Hematol Oncol, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Van Etten, Richard A.
Klingemann, Hans
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Tufts Med Ctr, Div Hematol Oncol, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
机构:
Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Boissel, Laurent
Betancura, Monica
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Betancura, Monica
Wels, Winfried S.
论文数: 0引用数: 0
h-index: 0
机构:
Chemotherapeut Forschungsinst Georg Speyer Haus, Frankfurt, GermanyTufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Wels, Winfried S.
Tuncer, Hande
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Med Ctr, Div Hematol Oncol, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Tuncer, Hande
Klingemann, Hans
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
Tufts Med Ctr, Div Hematol Oncol, Boston, MA 02111 USATufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
机构:University of Science and Technology of China,Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences
Min Cheng
Jian Zhang
论文数: 0引用数: 0
h-index: 0
机构:University of Science and Technology of China,Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences
Jian Zhang
Wen Jiang
论文数: 0引用数: 0
h-index: 0
机构:University of Science and Technology of China,Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences
Wen Jiang
Yongyan Chen
论文数: 0引用数: 0
h-index: 0
机构:University of Science and Technology of China,Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences
Yongyan Chen
Zhigang Tian
论文数: 0引用数: 0
h-index: 0
机构:University of Science and Technology of China,Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences
机构:
New York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USANew York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
Chu, Yaya
Hochberg, Jessica
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USANew York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
Hochberg, Jessica
Yahr, Ashlin
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USANew York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
Yahr, Ashlin
Ayello, Janet
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USANew York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
Ayello, Janet
van de Ven, Carmella
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USANew York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
van de Ven, Carmella
Barth, Matthew
论文数: 0引用数: 0
h-index: 0
机构:
SUNY Buffalo, Dept Pediat, Buffalo, NY 14260 USANew York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
Barth, Matthew
Czuczman, Myron
论文数: 0引用数: 0
h-index: 0
机构:
Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14263 USA
Roswell Pk Canc Inst, Dept Immunol, Buffalo, NY 14263 USANew York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
Czuczman, Myron
Cairo, Mitchell S.
论文数: 0引用数: 0
h-index: 0
机构:
New York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA
New York Med Coll, Dept Med, Valhalla, NY 10595 USA
New York Med Coll, Dept Pathol, Valhalla, NY 10595 USA
New York Med Coll, Dept Microbiol & Immunol, Valhalla, NY 10595 USA
New York Med Coll, Dept Cell Biol & Anat, Valhalla, NY 10595 USANew York Med Coll, Maria Fareri Childrens Hosp, Dept Pediat, Valhalla, NY 10595 USA