Synthesis of 2,3-dihydroimidazo[ 1,2-b]isoquinoline-5(1H)-one and derivatives

被引:10
作者
Bollini, M [1 ]
Asís, SE [1 ]
Bruno, AM [1 ]
机构
[1] Univ Buenos Aires, Ctr Sintesis & Estudio Nuevos Compuestos Antineop, Dept Quim Organ, Fac Farm & Bioquim, RA-1113 Buenos Aires, DF, Argentina
来源
SYNTHESIS-STUTTGART | 2006年 / 02期
关键词
acylation; DMAP; isomerizations; heterocycles; microwave synthesis;
D O I
10.1055/s-2005-918505
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A novel and efficient synthesis of 2,3-dihydroimidazo[1,2-b]isoquinoline-5(1H)-one by inicrowave irradiation is reported. Several new derivatives of 2,3-dihydroinlidazo[1,2-b]-lisoquinoline-5(1H)-one have been synthesized by acylation using DMAP as catalyst. A kinetic study employing HPLC allowed the determination of the N- and C-acylated isomers formed.
引用
收藏
页码:237 / 242
页数:6
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