A Sensitive H2O2 Assay Based on Dumbbell-like PtPd-Fe3O4 Nanoparticles

被引：205
作者：
Sun, Xiaolian [1 ]
Guo, Shaojun [1 ]
Chung, Chun-Shiang [2 ]
Zhu, Wenlei [1 ]
Sun, Shouheng [1 ]
机构：
[1] Brown Univ, Dept Chem, Providence, RI 02912 USA
[2] Brown Univ, Rhode Isl Hosp, Dept Surg, Providence, RI 02903 USA
来源：
ADVANCED MATERIALS | 2013年 / 25卷 / 01期
关键词：
PtPd alloy nanoparticles; Iron oxide nanoparticles; dumbbell nanoparticles; synergistic effect; H2O2; assay; PEROXIDASE-CATALYZED OXIDATION; HYDROGEN-PEROXIDE; ENDOTHELIAL-CELLS; NEUTROPHILS; STRESS; FE;
D O I：
10.1002/adma.201203218
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Dumbbell-like Pt48Pd52-Fe3O4 nanoparticles are synthesized and functionalized with oleylamine-polyethyleneglycol to serve as an efficient catalyst for H2O2 reduction and tetramethylbenzidine (TMB) oxidation in biological solutions. The Pt48Pd52-Fe3O4/TMB kit is even more active than the natural enzyme for H2O2 detection with a detection limit reaching 2 mu M, and is successfully used to quantitatively monitor the extracellular H2O2 generated by neutrophils.
引用
收藏
页码：132 / 136
页数：5
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