Single-fiber diffuse optical time-of-flight spectroscopy

被引：35

作者：

Alerstam, Erik ^{[1
]}

Svensson, Tomas ^{[1
]}

Andersson-Engels, Stefan ^{[1
]}

Spinelli, Lorenzo ^{[2
]}

Contini, Davide ^{[3
]}

Dalla Mora, Alberto ^{[3
]}

Tosi, Alberto ^{[4
]}

Zappa, Franco ^{[4
]}

Pifferi, Antonio ^{[2
,3
]}

机构：

[1] Lund Univ, Dept Phys, S-22100 Lund, Sweden

[2] CNR, Ist Foton & Nanotecnol, I-20133 Milan, Italy

[3] Politecn Milan, Dipartimento Fis, I-20133 Milan, Italy

[4] Politecn Milan, Dipartimento Elettron & Informaz, I-20133 Milan, Italy

来源：

OPTICS LETTERS | 2012年 / 37卷 / 14期

基金：

瑞典研究理事会;

关键词：

ABSORPTION PROPERTIES; NIR WAVELENGTHS; DYNAMIC-RANGE; SCATTERING; TISSUE; CALIBRATION; PROBE;

D O I：

10.1364/OL.37.002877

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We demonstrate interstitial diffuse optical time-of-fight spectroscopy based on a single fiber for both light delivery and detection. Detector saturation due to the massive short-time reflection is avoided by ultrafast gating of a single photon avalanche diode. We show that the effects of scattering and absorption are separable and that absorption can be assessed independently of scattering. Measurements on calibrated liquid phantoms and subsequent Monte Carlo-based evaluation illustrate that absorption coefficients can be accurately assessed over a wide range of medically relevant optical properties. Our findings pave the way to simplified and less invasive interstitial in vivo spectroscopy. (C) 2012 Optical Society of America

引用

收藏

页码：2877 / 2879

页数：3

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