One-pot synthesis of GABA amides via the nucleophilic addition of amines to 3,3-disubstituted cyclopropenes

被引：12
|
作者：
Maslivetc, Vladimir A. [1 ]
Rubina, Marina [1 ]
Rubin, Michael [1 ,2 ]
机构：
[1] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA
[2] North Caucasus State Univ, Dept Chem, Stavropol 355009, Russia
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 34期
基金：
俄罗斯基础研究基金会;
关键词：
BISTRAMIDE-A; EN-ROUTE; BROMOCYCLOPROPANES; SUBSTITUTION; DERIVATIVES; DESIGN; PHARMACOLOGY; INHIBITORS; ANALOGS; DRUG;
D O I：
10.1039/c5ob01462j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot synthesis of various GABA amides has been demostrated, employing the nucleophilic addition of primary and secondary amines across the double bond of cyclopropene-3-carboxamides, followed by ring-opening of the resulting donor-acceptor cyclopropanes and subsequent in situ reduction of enamine (imine) intermediates.
引用
收藏
页码：8993 / 8995
页数：3
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