Incorporation of silver and strontium in hydroxyapatite coating on titanium surface for enhanced antibacterial and biological properties

被引：109

作者：

Geng, Zhen ^{[1
]}

Wang, Renfeng ^{[3
]}

Zhuo, Xianglong ^{[4
]}

Li, Zhaoyang ^{[1
,2
]}

Huang, Yongcan ^{[5
]}

Ma, Lili ^{[1
]}

Cui, Zhenduo ^{[1
]}

Zhu, Shengli ^{[1
,2
]}

Liang, Yanqin ^{[1
]}

Liu, Yunde ^{[3
]}

Bao, Huijing ^{[3
]}

Li, Xue ^{[3
]}

Huo, Qianyu ^{[3
]}

Liu, Zhili ^{[3
]}

Yang, Xianjin ^{[1
,2
]}

机构：

[1] Tianjin Univ, Sch Mat Sci & Engn, 92 Weijin Rd, Tianjin 300072, Peoples R China

[2] Tianjin Key Lab Composite & Funct Mat, Tianjin 300072, Peoples R China

[3] Tianjin Med Univ, Sch Lab Med, Tianjin 300072, Peoples R China

[4] Liuzhou Workers Hosp, Dept Spinal Surg, Liuzhou 545001, Peoples R China

[5] Peking Univ, Shenzhen Hosp, Orthoped Res Ctr, Shenzhen 518036, Peoples R China

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 71卷

基金：

中国国家自然科学基金;

关键词：

Hydroxyapatite coating; Silver; Strontium; Antibacterial property; Bioactivity; CALCIUM-PHOSPHATE; IN-VIVO; SUBSTITUTED HYDROXYAPATITE; BIOMEDICAL APPLICATIONS; STAPHYLOCOCCUS-AUREUS; ANTIBIOTIC-RESISTANCE; ESCHERICHIA-COLI; BONE RESPONSE; IMPLANTS; ADHESION;

D O I：

10.1016/j.msec.2016.10.079

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Implant-related infection in primary total joint prostheses has attracted considerable research attention, As a measure to improve the antimicrobial properties of implant materials, silver (Ag) was incorporated into calcium phosphate (CaP) coatings on Titanium (Ti) via a hydrothermal method. Further, strontium (Sr) was added as a binary dopant to reduce the cytotoxicity of Ag in the coatings. Results showed that the CaP coatings were uniformly deposited on Ti with enhanced hydrophilicity and nanoscale surface roughness. Moreover, cell adhesion, proliferation, and differentiation were improved after the CaP coating deposition, The antibacterial properties of the coatings were distinctly improved by the incorporation of Ag, but the cell proliferation and differentiation were significantly decreased. Owing to the incorporation of Sr, the Ag-CaP coatings were able to effectively counteract the negative effects of Ag while maintaining good antibacterial properties. In summary, hydrothermally deposited CaP coatings doped with Ag and Sr exhibit excellent biocompatibility and antimicrobial activity. Thus, such co-doped CaP coatings have considerable potential for orthopedic implant modification. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：852 / 861

页数：10

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