Doubly Biomimetic Catecholic Phosphorylcholine Copolymer: A Platform Strategy for Fabricating Antifouling Surfaces

被引：65
作者：
Gong, Yong-Kuan [1 ]
Liu, Li-Ping [1 ]
Messersmith, Phillip B. [2 ,3 ]
机构：
[1] Northwest Univ, Coll Chem & Mat Sci, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Peoples R China
[2] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA
[3] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA
来源：
MACROMOLECULAR BIOSCIENCE | 2012年 / 12卷 / 07期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
antifouling; biomimetic; catechol; coatings; phosphorylcholine; TRANSFER RADICAL POLYMERIZATION; MUSSEL ADHESIVE; BIOMEDICAL APPLICATIONS; PROTEIN ADSORPTION; 2-METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE; POLY(ETHYLENE GLYCOL); PHOSPHOLIPID POLYMERS; RESISTANT SURFACES; CELL-ADHESION; CROSS-LINKING;
D O I：
10.1002/mabi.201200074
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A doubly biomimetic PMNC polymer bearing cell antifouling phosphorylcholine and mussel adhesive protein catechol groups is synthesized. The polymer can be deposited onto a variety of substrates by dip-coating in an aqueous solution, adhering to surfaces via the catechol functional group while at the same time forming a cell outer membrane mimetic antifouling surface. Contact angle, ATR-FTIR and XPS measurements confirm polymer coating formation on a variety of inorganic and organic substrates. BSA and bovine plasma fibrinogen protein adsorption on PMNC coated surfaces are reduced significantly compared to unmodified substrates, and platelet adhesion from human serum onto the PMNC coated substrate surfaces is highly suppressed in this study.
引用
收藏
页码：979 / 985
页数：7
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