Adiponectin through its biphasic serum level is a useful biomarker during transition from diastolic dysfunction to systolic dysfunction - an experimental study

被引:13
作者
Fu, Mingqiang [1 ]
Zhou, Jingmin [1 ]
Qian, Juying [1 ]
Jin, Xuejuan [1 ]
Zhu, Hongmin [1 ]
Zhong, Chunlin [1 ]
Fu, Michael [2 ]
Zou, Yunzeng [1 ,3 ]
Ge, Junbo [1 ,3 ]
机构
[1] Fudan Univ, Dept Cardiol, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai 200433, Peoples R China
[2] Sahlgrens Univ Hosp, Dept Med, Gothenburg, Sweden
[3] Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China
基金
中国国家自然科学基金;
关键词
Hypertension; Diastolic function; Systolic function; Adiponectin; Biomarker; LEFT-VENTRICULAR MASS; HEART-FAILURE; NATRIURETIC PEPTIDE; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; PLASMA ADIPONECTIN; ADIPOSE-TISSUE; HYPERTENSION; ECHOCARDIOGRAPHY; EXPRESSION;
D O I
10.1186/1476-511X-11-106
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Adiponectin is reported to relate with cardiovascular diseases, we sought to examine whether adiponectin is associated with disease progression of heart failure from hypertension in rats in comparison with other known biomarkers and echocardiographic parameters. Spontaneously hypertensive rats (SHR, n = 35), aged 1 month, were used and followed up to 18 months. High frequency echocardiography was performed both at baseline and every 3 months thereafter. Moreover, serum levels of N-terminal pro-natriuretic peptide (NT-proBNP) and interleukin-6 (IL-6) as well as serum level and tissue expression of adiponectin were determined at the same time as echocardiography. Results: The results clearly demonstrated time-dependent progression of hypertension and heart dysfunction as evidenced by gradually increased left ventricular mass index, NT-proBNP, IL-6 as well as gradually decreased cardiac function as assessed by echocardiography. Meanwhile, tissue and serum adiponectin decreased from 3 months and reached plateau until 12 months in parallel with decreasing of cardiac diastolic function. Thereafter, adiponectin levels increased prior to occurrence of systolic dysfunction. Adiponectin concentration is inversely related with NT-proBNP, IL-6 and E/E' (correlation coefficient (r) = -0.756 for NT-proBNP, p < 0.001, -0.635 for IL-6, p = 0.002, and -0.626 for E/E', p = 0.002, respectively) while positively correlated with E/A and E'/A' (r = 0.683 for E/A, p = 0.001, 0.671 for E'/A', p = 0.001, respectively). No difference for adiponectin distribution among visceral adipose tissues was found. Conclusion: Adiponectin through its biphasic serum level is a useful biomarker during transition from diastolic dysfunction to systolic dysfunction.
引用
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页数:10
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