Important role of Maillard reaction in the protective effect of heat-processed ginsenoside Re-serine mixture against cisplatin-induced nephrotoxicity in LLC-PK1 cells

被引：12

作者：

Lee, Ji Hwan ^{[1
]}

Lee, Woojung ^{[1
]}

Lee, Seungyong ^{[1
]}

Jung, Yujung ^{[1
]}

Park, Soon-Hye ^{[1
]}

Choi, Pilju ^{[1
]}

Kim, Su-Nam ^{[1
]}

Ham, Jungyeob ^{[1
]}

Kang, Ki Sung ^{[1
]}

机构：

[1] Korea Inst Sci & Technol, Nat Med Ctr, Kangnung 210340, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 17期

关键词：

Maillard reaction; Ginsenoside Re; Oxidative stress; Nephrotoxicity; Heat-processing; RADICAL SCAVENGING ACTIVITY; ANTIOXIDATIVE ACTIVITIES; INHIBITION;

D O I：

10.1016/j.bmcl.2012.07.018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aim of the present study was to verify the important role of Maillard reaction in the protective effect of heat-processed ginsenoside Re-serine mixture against oxidative stress-induced nephrotoxicity. The free radical-scavenging activity of ginsenoside Re-serine mixture was increased by heat-processing. Ginsenoside Re was transformed into less-polar ginsenosides such as Rg(2), Rg(6) and F-4 by heat-processing, and the glucose molecule at carbon-20 was separated. The improved-free radical-scavenging activity by heat-processing was mediated by the generation of antioxidant Maillard reaction products (MRPs) from the reaction of glucose with serine. Moreover, MRPs from ginsenoside Re-serine mixture showed protective effect against cisplatin-induced renal epithelial cell damage. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：5475 / 5479

页数：5

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