NF-κB as potential target in the treatment of melanoma

被引：119

作者：

Madonna, Gabriele ^{[1
]}

Ullman, Claudio Dansky ^{[2
]}

Gentilcore, Giusy ^{[1
]}

Palmieri, Giuseppe ^{[3
]}

Ascierto, Paolo Antonio ^{[1
]}

机构：

[1] Ist Nazl Tumori Fdn, Unit Med Oncol & Innovat Therapy, Naples, Italy

[2] NCI, Canc Therapy Evaluat Program, Bethesda, MD 20892 USA

[3] CNR, Inst Biomol Chem, Sassari, Italy

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2012年 / 10卷

关键词：

NF-kappa B; Melanoma; NBD peptide; Bortezomib; Curcumin; NEMO-BINDING DOMAIN; STAGE-IV MELANOMA; MALIGNANT-MELANOMA; SIGNALING PATHWAY; PHASE-II; CELLS; KINASE; CURCUMIN; ACTIVATION; EXPRESSION;

D O I：

10.1186/1479-5876-10-53

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The RAS/MAP kinase pathway has attracted attention because activating mutations of the BRAF serine/threonine kinase was described in over 50% of melanomas. Very recently, selective and potent BRAF inhibitors have been developed. Several other signal transduction pathways have been found to be constitutively active or mutated in other subsets of melanoma tumors that are potentially targetable with new agents. Among these, NF kappa B is another pathway that melanoma tumors use to achieve survival, proliferation and resistance to apoptosis. Inhibition of NF kappa B activation appears to be a very promising option for anti-cancer therapies.

引用

页数：8

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