Haemodynamics in women with untreated pre-eclampsia*

被引：70
作者：
Dennis, A. T. [1 ,2 ]
Castro, J. [3 ]
Carr, C.
Simmons, S. [2 ,4 ]
Permezel, M. [5 ]
Royse, C. [2 ,6 ]
机构：
[1] Univ Melbourne, Dept Anaesthesia, Royal Womens Hosp Parkville, Melbourne, Vic 3010, Australia
[2] Univ Melbourne, Dept Pharmacol, Melbourne, Vic 3010, Australia
[3] St Vincents Hosp, Dept Cardiol, Fitzroy, Vic 3065, Australia
[4] Mercy Hosp Women, Dept Anaesthesia, Heidelberg, Vic, Australia
[5] Mercy Hosp Women, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia
[6] Royal Melbourne Hosp, Dept Anaesthesia & Pain Management, Parkville, Vic 3050, Australia
来源：
ANAESTHESIA | 2012年 / 67卷 / 10期
关键词：
OF-ECHOCARDIOGRAPHYS GUIDELINES; CARDIAC-OUTPUT; STANDARDS COMMITTEE; PULMONARY-EDEMA; HYPERTENSIVE DISORDERS; MATERNAL HEMODYNAMICS; DIASTOLIC FUNCTION; TASK-FORCE; PREECLAMPSIA; DOPPLER;
D O I：
10.1111/j.1365-2044.2012.07193.x
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
This study aimed to compare the haemodynamics in healthy pregnant women with the haemodynamics in women with untreated pre-eclampsia, to determine the cardiovascular reason for hypertension in pre-eclampsia. 40 women with untreated pre-eclampsia, 40 matched healthy pregnant women and 20 non-pregnant women were studied using transthoracic echocardiography. Untreated pre-eclampsia demonstrated (mean (SD), healthy non-pregnant vs healthy pregnant vs untreated pre-eclampsia) increased cardiac output (3400 (752) vs 4109 (595) vs 4789 (1416) ml.min-1, p = 0.002), increased stroke volume (53 (10) vs 53 (8) vs 59 (13) ml, p = 0.04), increased fractional shortening (35 (5) vs 35 (7) vs 41 (8) %, p = 0.006), increased fractional area change (57 (7) vs 57 (9) vs 65 (9) %, p = 0.002) and increased systemic vascular resistance (2116 (457) vs 1613 (315) vs 2016 (625) dyne.s.cm-5, p = 0.001). Mitral E/septal e' was higher (6.0 (1.1) vs 6.7 (1.3) vs 10.4 (2.4), p = 0.002) and left atrial size increased (3.2 (0.3) vs 3.8 (0.4) vs 4.0 (0.4) cm, p = 0.002). Hypertension in untreated pre-eclampsia is due to increased cardiac output and mild vasoconstriction, with increased inotropy and reduced diastolic function.
引用
收藏
页码：1105 / 1118
页数：14
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