Water-Dispersible Ferrimagnetic Iron Oxide Nanocubes with Extremely High r2 Relaxivity for Highly Sensitive in Vivo MRI of Tumors

被引：249
作者：
Lee, Nohyun [3 ,4 ]
Choi, Yoonseok [1 ,2 ]
Lee, Youjin [3 ,4 ]
Park, Mihyun [3 ,4 ]
Moon, Woo Kyung [1 ,2 ]
Choi, Seung Hong [1 ,2 ]
Hyeon, Taeghwan [3 ,4 ]
机构：
[1] Seoul Natl Univ, Seoul Natl Univ Hosp, Seoul 110744, South Korea
[2] Seoul Natl Univ, Med Res Ctr, Inst Radiat Med, Seoul 110744, South Korea
[3] Seoul Natl Univ, World Class Univ Program Chem Convergence Energy, Inst Chem Proc, Seoul 151744, South Korea
[4] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 151744, South Korea
来源：
NANO LETTERS | 2012年 / 12卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
Nanoparticle; nanomedicine; iron oxide; magnetic resonance imaging contrast agent; colloidal stability; PERFORMANCE MAGNETIC-RESONANCE; NANOPARTICLE PROBES; FE3O4; NANOPARTICLES; CONTROLLED-RELEASE; FUNCTIONALIZATION; CELLS; FLUORESCENCE; PARTICLES; DELIVERY; SPHERES;
D O I：
10.1021/nl3010308
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The theoretically predicted maximum r(2) relaxivity of iron oxide nanoparticles was achieved by optimizing the overall size of ferrimagnetic iron oxide nanocubes. Uniform-sized iron oxide nanocubes with an edge length of 22 nm, encapsulated with PEG-phospholipids (WFION), exhibited high colloidal stability in aqueous media. In addition, WFIONs are biocompatible and did not affect cell viability at concentrations up to 0.75 mg Fe/ml. Owing to the enhanced colloidal stability and the high r(2) relaxivity (761 mM(-1) s(-1)), it was possible to successfully perform in vivo MR imaging of tumors by intravenous injection of 22-nm-sized WFIONs, using a clinical 3-T MR scanner.
引用
收藏
页码：3127 / 3131
页数：5
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