HIV-coinfection leads to a modest increase in plasma HCV-RNA load in patients with chronic HCV infection

被引：10

作者：

Neukam, Karin ^{[1
]}

Garcia-Rey, Silvia ^{[1
]}

Cifuentes, Celia ^{[1
]}

Macias, Juan ^{[1
]}

Mira, Jose A. ^{[1
,2
]}

Vazquez, Maria J. ^{[3
]}

Parra-Sanchez, Manuel ^{[1
]}

Palomares, Jose C. ^{[1
]}

Merchante, Nicolas ^{[1
]}

Di Lello, Federico A. ^{[1
]}

Pineda, Juan A. ^{[1
]}

机构：

[1] Hosp Univ Valme, Unit Infect Dis & Microbiol, Seville 41014, Spain

[2] Hosp Univ Valme, Dept Internal Med, Seville 41014, Spain

[3] Ctr Penitenciario Sevilla, Med Serv, Alcala De Guadaira 41500, Spain

来源：

ANTIVIRAL RESEARCH | 2012年 / 95卷 / 03期

关键词：

Hepatitis C virus; HIV; RNA load; Pegylated interferon; Ribavirin; Polymerase chain reaction; HEPATITIS-C VIRUS; INTERFERON PLUS RIBAVIRIN; ANTIRETROVIRAL THERAPY; PREDICTION; COHORT;

D O I：

10.1016/j.antiviral.2012.06.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of HIV coinfection on plasma hepatitis C virus (HCV) RNA load has not been reliably evaluated. We analyzed plasma HCV RNA load in 396 HCV-monoinfected and 467 HIV/HCV-coinfected patients. Median HCV RNA concentrations (interquartile range) in HCV-monoinfected patients were 5.88 (5.3-6.2) log(10) IU/mL versus 5.96 (5.6-6.5) log(10) IU/mL in HIV/HCV-coinfected individuals (p = 0.033) as determined with the Cobas Amplicor Test and 6.06 (5.4-5.7) log(10) IU/mL versus 6.3 (5.5-6.9) log(10) IU/mL (p = 0.026) using the Cobas TaqMan System. The plasma HCV RNA load in patients with HIV infection and undetectable plasmatic HIV RNA was similar to that observed in HCV-monoinfected individuals [6.02 (5.45-6.61) log(10) IU/mL versus 6.01 (5.36-6.59) log(10) IU/mL, respectively (p = 1.0)]. In conclusion, HIV coinfection tends to be associated with higher plasma HCV RNA load, however, the magnitude of the differences is small and this effect can be counterbalanced with antiviral therapy. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：212 / 215

页数：4

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