Different Effects of Different Lactobacillus acidophilus Strains on DSS-Induced Colitis

被引：7
作者：
Huang, Zheng [1 ,2 ]
Gong, Lei [3 ]
Jin, Yan [3 ]
Stanton, Catherine [4 ,5 ,6 ]
Ross, Reynolds Paul [4 ,5 ]
Zhao, Jianxin [1 ,2 ,7 ]
Yang, Bo [1 ,2 ,4 ]
Chen, Wei [1 ,2 ,7 ]
机构：
[1] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Peoples R China
[2] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Peoples R China
[3] Nanjing Med Univ, Affiliated Wuxi Peoples Hosp 2, Dept Gastroenterol, Wuxi 214122, Peoples R China
[4] Jiangnan Univ, Int Joint Res Lab Pharmabiot & Antibiot Resistance, Wuxi 214122, Peoples R China
[5] Univ Coll Cork, APC Microbiome Ireland, Cork T12 K8AF, Ireland
[6] Teagasc Food Res Ctr, Moorepark, Fermoy P61 C996, Cork, Ireland
[7] Jiangnan Univ, Natl Engn Res Ctr Funct Food, Wuxi 214122, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 23期
基金：
中国国家自然科学基金;
关键词：
Lactobacillus acidophilus; colitis; cytokines; gut microbiota; SCFAs; INDUCED ULCERATIVE-COLITIS; DEXTRAN SULFATE SODIUM; COLORECTAL CARCINOGENESIS; ESCHERICHIA-COLI; GUT MICROBIOTA; INFLAMMATION; METABOLISM; RECEPTOR; METASTASIS; SIGNATURE;
D O I：
10.3390/ijms232314841
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inflammatory bowel disease (IBD) is a worldwide chronic intestinal inflammatory immune-related disease. In this study, mice with dextran sulfate sodium (DSS)-induced colitis were used to evaluate the effect of Lactobacillus acidophilus on colitis. The results revealed that L. acidophilus CCFM137 and FAHWH11L56 show potential for relieving colitis symptoms, while L. acidophilus FGSYC48L79 did not show a protective effect. Moreover, L. acidophilus NCFM and FAHWH11L56 showed similar effects on various indicators of DSS-induced colitis, increasing the IL-10 and IL-17 in the colon, and modifying the CCL2/CCR2 axis and CCL3/CCR1 axis. For L. acidophilus CCFM137, its effects on colitis were different from the above two strains. Moreover, L. acidophilus FGSYC48L79 had negative effects on colitis by increasing the abundance of harmful bacteria in the gut microbiota and may promote the signaling of chemokines and their receptors. This may be related to its special genome compared to the other strains.
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页数：18
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