Different Effects of Different Lactobacillus acidophilus Strains on DSS-Induced Colitis

被引：7
作者：
Huang, Zheng [1 ,2 ]
Gong, Lei [3 ]
Jin, Yan [3 ]
Stanton, Catherine [4 ,5 ,6 ]
Ross, Reynolds Paul [4 ,5 ]
Zhao, Jianxin [1 ,2 ,7 ]
Yang, Bo [1 ,2 ,4 ]
Chen, Wei [1 ,2 ,7 ]
机构：
[1] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Peoples R China
[2] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Peoples R China
[3] Nanjing Med Univ, Affiliated Wuxi Peoples Hosp 2, Dept Gastroenterol, Wuxi 214122, Peoples R China
[4] Jiangnan Univ, Int Joint Res Lab Pharmabiot & Antibiot Resistance, Wuxi 214122, Peoples R China
[5] Univ Coll Cork, APC Microbiome Ireland, Cork T12 K8AF, Ireland
[6] Teagasc Food Res Ctr, Moorepark, Fermoy P61 C996, Cork, Ireland
[7] Jiangnan Univ, Natl Engn Res Ctr Funct Food, Wuxi 214122, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 23期
基金：
中国国家自然科学基金;
关键词：
Lactobacillus acidophilus; colitis; cytokines; gut microbiota; SCFAs; INDUCED ULCERATIVE-COLITIS; DEXTRAN SULFATE SODIUM; COLORECTAL CARCINOGENESIS; ESCHERICHIA-COLI; GUT MICROBIOTA; INFLAMMATION; METABOLISM; RECEPTOR; METASTASIS; SIGNATURE;
D O I：
10.3390/ijms232314841
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inflammatory bowel disease (IBD) is a worldwide chronic intestinal inflammatory immune-related disease. In this study, mice with dextran sulfate sodium (DSS)-induced colitis were used to evaluate the effect of Lactobacillus acidophilus on colitis. The results revealed that L. acidophilus CCFM137 and FAHWH11L56 show potential for relieving colitis symptoms, while L. acidophilus FGSYC48L79 did not show a protective effect. Moreover, L. acidophilus NCFM and FAHWH11L56 showed similar effects on various indicators of DSS-induced colitis, increasing the IL-10 and IL-17 in the colon, and modifying the CCL2/CCR2 axis and CCL3/CCR1 axis. For L. acidophilus CCFM137, its effects on colitis were different from the above two strains. Moreover, L. acidophilus FGSYC48L79 had negative effects on colitis by increasing the abundance of harmful bacteria in the gut microbiota and may promote the signaling of chemokines and their receptors. This may be related to its special genome compared to the other strains.
引用
收藏
页数：18
相关论文
共 55 条
  • [1] CCL3/MIP-1α is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4+ T cells to the liver
    Ajuebor, MN
    Hogaboam, CM
    Le, T
    Proudfoot, AEI
    Swain, MG
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (10) : 2907 - 2918
  • [2] Microbial imbalance in inflammatory bowel disease patients at different taxonomic levels
    Alam, Mohammad Tauqeer
    Amos, Gregory C. A.
    Murphy, Andrew R. J.
    Murch, Simon
    Wellington, Elizabeth M. H.
    Arasaradnam, Ramesh P.
    [J]. GUT PATHOGENS, 2020, 12 (01)
  • [3] Involvement of interleukin-1 in the development of ulcerative colitis induced by dextran sulfate sodium in mice
    Arai, Y
    Takanashi, H
    Kitagawa, H
    Okayasu, I
    [J]. CYTOKINE, 1998, 10 (11) : 890 - 896
  • [4] Intestinal microbiota: A source of novel biomarkers in inflammatory bowel diseases?
    Berry, David
    Reinisch, Walter
    [J]. BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2013, 27 (01) : 47 - 58
  • [5] Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2
    Bolyen, Evan
    Rideout, Jai Ram
    Dillon, Matthew R.
    Bokulich, NicholasA.
    Abnet, Christian C.
    Al-Ghalith, Gabriel A.
    Alexander, Harriet
    Alm, Eric J.
    Arumugam, Manimozhiyan
    Asnicar, Francesco
    Bai, Yang
    Bisanz, Jordan E.
    Bittinger, Kyle
    Brejnrod, Asker
    Brislawn, Colin J.
    Brown, C. Titus
    Callahan, Benjamin J.
    Caraballo-Rodriguez, Andres Mauricio
    Chase, John
    Cope, Emily K.
    Da Silva, Ricardo
    Diener, Christian
    Dorrestein, Pieter C.
    Douglas, Gavin M.
    Durall, Daniel M.
    Duvallet, Claire
    Edwardson, Christian F.
    Ernst, Madeleine
    Estaki, Mehrbod
    Fouquier, Jennifer
    Gauglitz, Julia M.
    Gibbons, Sean M.
    Gibson, Deanna L.
    Gonzalez, Antonio
    Gorlick, Kestrel
    Guo, Jiarong
    Hillmann, Benjamin
    Holmes, Susan
    Holste, Hannes
    Huttenhower, Curtis
    Huttley, Gavin A.
    Janssen, Stefan
    Jarmusch, Alan K.
    Jiang, Lingjing
    Kaehler, Benjamin D.
    Bin Kang, Kyo
    Keefe, Christopher R.
    Keim, Paul
    Kelley, Scott T.
    Knights, Dan
    [J]. NATURE BIOTECHNOLOGY, 2019, 37 (08) : 852 - 857
  • [6] Anti-inflammatory activity of surface layer protein SlpA of Lactobacillus acidophilus CICC 6074 in LPS-induced RAW 264.7 cells and DSS-induced mice colitis
    Cai, Zhendong
    Xu, Puxu
    Wu, Zhen
    Pan, Daoding
    [J]. JOURNAL OF FUNCTIONAL FOODS, 2018, 51 : 16 - 27
  • [7] Lactobacillus acidophilus Suppresses Colitis-Associated Activation of the IL-23/Th17 Axis
    Chen, Linlin
    Zou, Yiyou
    Peng, Jie
    Lu, Fanggen
    Yin, Yani
    Li, Fujun
    Yang, Junwen
    [J]. JOURNAL OF IMMUNOLOGY RESEARCH, 2015, 2015
  • [8] Characteristics of Fecal and Mucosa-Associated Microbiota in Chinese Patients With Inflammatory Bowel Disease
    Chen, Liping
    Wang, Wei
    Zhou, Rui
    Ng, Siew C.
    Li, Jin
    Huang, Meifang
    Zhou, Feng
    Wang, Xin
    Shen, Bo
    Kamm, Michael A.
    Wu, Kaichun
    Xia, Bing
    [J]. MEDICINE, 2014, 93 (08)
  • [9] Orally Administered CLA Ameliorates DSS-Induced Colitis in Mice via Intestinal Barrier Improvement, Oxidative Stress Reduction, and Inflammatory Cytokine and Gut Microbiota Modulation
    Chen, Yang
    Yang, Bo
    Ross, R. Paul
    Jin, Yan
    Stanton, Catherine
    Zhao, Jianxin
    Zhang, Hao
    Chen, Wei
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 67 (48) : 13282 - 13298
  • [10] CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function
    Chun, Eunyoung
    Lavoie, Sydney
    Michaud, Monia
    Gallini, Carey Ann
    Kim, Jason
    Soucy, Genevieve
    Odze, Robert
    Glickman, Jonathan N.
    Garrett, Wendy S.
    [J]. CELL REPORTS, 2015, 12 (02): : 244 - 257
123456