Recent advances in AIDS-related cryptococcal meningitis treatment with an emphasis on resource limited settings

被引：19
作者：
Lofgren, Sarah [1 ,2 ]
Abassi, Mahsa [1 ,2 ]
Rhein, Joshua [1 ,2 ]
Boulware, David R. [1 ]
机构：
[1] Univ Minnesota, Dept Med, Div Infect Dis & Int Med, MMC 250,420 Delaware St SE, Minneapolis, MN 55455 USA
[2] Makerere Univ, Infect Dis Inst, Kampala, Uganda
来源：
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2017年 / 15卷 / 04期
基金：
美国国家卫生研究院;
关键词：
HIV; AIDS; cryptococcal meningitis; CM-IRIS; immune reconstitution inflammatory syndrome; review; antiretroviral therapy; antifungal therapy; sertraline; HIGH-DOSE FLUCONAZOLE; LATERAL FLOW ASSAY; RECONSTITUTION INFLAMMATORY SYNDROME; COLONY-STIMULATING FACTOR; EARLY FUNGICIDAL ACTIVITY; LIPOSOMAL AMPHOTERICIN-B; PLACEBO-CONTROLLED TRIAL; ANTIRETROVIRAL THERAPY; INTRACRANIAL-PRESSURE; MAINTENANCE THERAPY;
D O I：
10.1080/14787210.2017.1285697
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Introduction: Recent advances in the treatment and prevention of cryptococcal meningitis have the potential to decrease AIDS-related deaths.Areas covered: Targeted screening for asymptomatic cryptococcal antigenemia in persons with AIDS is a cost effective method for reducing early mortality in patients on antiretroviral therapy. For persons with symptomatic cryptococcal meningitis, optimal initial management with amphotericin and flucytosine improves survival compared to alternative therapies; however, amphotsericin is difficult to administer and flucytosine has not been available in middle or low income countries, where cryptococcal meningitis is most prevalent.Expert commentary: Improved care for cryptococcal meningitis patients in resource-limited settings is possible, and new treatment possibilities are emerging.
引用
收藏
页码：331 / 340
页数：10
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