Metal-N-Heterocyclic Carbene Complexes as Anti-Tumor Agents

被引：54

作者：

Hu, Chunqi ^{[1
]}

Li, Xin ^{[2
]}

Wang, Wei ^{[3
]}

Zhang, Ruoyu ^{[4
]}

Deng, Liping ^{[1
,3
]}

机构：

[1] Shaoxing Univ, Dept Pharmacol, Chem & Chem Engn Inst, Shaoxing 312000, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Pharmaceut Sci, ZJU ENS Joint Lab Med Chem, Hangzhou 310058, Zhejiang, Peoples R China

[3] Zhejiang Supor Pharmaceut, Shaoxing 312000, Zhejiang, Peoples R China

[4] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Geriatr, Hangzhou 310009, Zhejiang, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2014年 / 21卷 / 10期

基金：

美国国家科学基金会;

关键词：

NHCs; NHC-metal complexes; anti-tumor; biological evaluation; MITOCHONDRIAL PERMEABILITY TRANSITION; IN-VITRO; STRUCTURAL-CHARACTERIZATION; ANTICANCER PROPERTIES; SURVIVIN SUPPRESSANT; PHOSPHINE COMPLEXES; PLATINUM COMPLEXES; GOLD(I) COMPLEXES; SILVER; CYTOTOXICITY;

D O I：

10.2174/0929867321666131217161849

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been a long story of the development of anticancer metallopharmaceuticals since the identification of cisplatin. Advances in metallodrugs discovery during the past 40 years have made it an ever-growing area of research in medicinal inorganic chemistry. Meanwhile, the emerging of N-heterocyclic carbene (NHC) chemistry has stimulated the newly burgeoning interests in the biomedical applications of metal-NHC complexes. This review will detail what have been achieved hitherto in the research of metal-NHC complexes as potential anti-tumor agents coupled with gold, silver, copper, platinum and palladium. Their mechanism of action will also be discussed. All the results obtained indicate that this promising approach is worthy of more focuses and further studies.

引用

页码：1220 / 1230

页数：11

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