Building a developmental toxicity ontology

被引：19

作者：

Baker, Nancy ^{[1
]}

Boobis, Alan ^{[2
]}

Burgoon, Lyle ^{[3
]}

Carney, Edward ^{[4
]}

Currie, Richard ^{[5
]}

Fritsche, Ellen ^{[6
]}

Knudsen, Thomas ^{[7
]}

Laffont, Madeleine ^{[8
]}

Piersma, Aldert H. ^{[9
,10
]}

Poole, Alan ^{[8
]}

Schneider, Steffen ^{[11
]}

Daston, George ^{[12
]}

机构：

[1] Lockheed Martin, Piedmont, NC USA

[2] Imperial Coll London, Dept Med, London, England

[3] US Army Engineer Res & Dev Ctr, Raleigh, NC USA

[4] Dow, Midland, MI USA

[5] Syngenta, Reading, Berks, England

[6] IUF Leibniz Res Inst, Dusseldorf, Germany

[7] US EPA, Piedmont, NC USA

[8] European Ctr Ecotoxicol & Toxicol Chem ECETOC, Brussels, Belgium

[9] Natl Inst Publ Hlth & Environm RIVM, Ctr Hlth Protect, Bilthoven, Netherlands

[10] Univ Utrecht, Inst Risk Assessment Sci IRAS, Utrecht, Netherlands

[11] BASF SE, GB-T-Z470, Ludwigshafen, Germany

[12] Procter & Gamble Co, Cent Prod Safety Dept, Mason, OH USA

来源：

BIRTH DEFECTS RESEARCH | 2018年 / 110卷 / 06期

关键词：

development; framework; ontology; retinoic acid; toxicity; VITAMIN-A-DEFICIENCY; RETINOIC ACID; TOXICOLOGY BERLIN; MOUSE; TERMINOLOGY; HARMONIZATION; HINDBRAIN; WORKSHOP; DEFECTS; PATTERN;

D O I：

10.1002/bdr2.1189

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

BackgroundAs more information is generated about modes of action for developmental toxicity and more data are generated using high-throughput and high-content technologies, it is becoming necessary to organize that information. This report discussed the need for a systematic representation of knowledge about developmental toxicity (i.e., an ontology) and proposes a method to build one based on knowledge of developmental biology and mode of action/ adverse outcome pathways in developmental toxicity. MethodsThis report is the result of a consensus working group developing a plan to create an ontology for developmental toxicity that spans multiple levels of biological organization. ResultsThis report provide a description of some of the challenges in building a developmental toxicity ontology and outlines a proposed methodology to meet those challenges. As the ontology is built on currently available web-based resources, a review of these resources is provided. Case studies on one of the most well-understood morphogens and developmental toxicants, retinoic acid, are presented as examples of how such an ontology might be developed. DiscussionThis report outlines an approach to construct a developmental toxicity ontology. Such an ontology will facilitate computer-based prediction of substances likely to induce human developmental toxicity.

引用

页码：502 / 518

页数：17

共 72 条

[1] The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures [J].