Correlations between severity of clinical signs and histopathological changes in 60 dogs with spinal cord injury associated with acute thoracolumbar intervertebral disc disease

被引:33
作者
Henke, D. [1 ]
Vandevelde, M. [1 ]
Doherr, M. G. [2 ]
Stoeckli, M. [3 ]
Forterre, F. [3 ]
机构
[1] Univ Bern, Vetsuisse Fac, Dept Clin Vet Med, Div Clin Neurol, CH-3001 Bern, Switzerland
[2] Univ Bern, Vetsuisse Fac, Vet Publ Hlth Inst, CH-3012 Bern, Switzerland
[3] Univ Bern, Vetsuisse Fac, Dept Clin Vet Med, Div Clin Surg, CH-3001 Bern, Switzerland
关键词
Canine; Intervertebral disc extrusion; Schiff-Sherrington posture; HERNIATION; LESIONS; REFLEX;
D O I
10.1016/j.tvjl.2013.04.003
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
The outcome of spinal surgery in dogs with absent voluntary motor function and nociception following intervertebral disc (IVD) herniation is highly variable, which likely attests to differences in the severity of spinal cord damage. This retrospective study evaluated the extent to which neurological signs correlated with histologically detected spinal cord damage in 60 dogs that were euthanased because of thoracolumbar IVD herniation. Clinical neurological grades correlated significantly with the extent of white matter damage (P < 0.001). However, loss of nociception also occurred in 6/31 (19%) dogs with relatively mild histological changes. The duration of clinical signs, Schiff-Sherrington posture, loss of reflexes and pain on spinal palpation were not significantly associated with the severity of spinal cord damage. Although clinical-pathological correlation was generally good, some clinical signs frequently thought to indicate severe cord injury did not always correlate with the degree of cord damage, suggesting functional rather than structural impairment in some cases. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码:70 / 75
页数:6
相关论文
共 30 条
[1]  
Coates J R., 2004, BSAVA Manual of Canine and Feline Neurology, V3rd, P237
[2]   High-Energy Contact Sports and Cervical Spine Neuropraxia Injuries What Are the Criteria for Return to Participation? [J].
Dailey, Andrew ;
Harrop, James S. ;
France, John C. .
SPINE, 2010, 35 (21) :S193-S201
[3]   Spinal shock revisited: a four-phase model [J].
Ditunno, JF ;
Little, JW ;
Tessler, A ;
Burns, AS .
SPINAL CORD, 2004, 42 (07) :383-395
[4]   Spinal cord swelling as a myelographic indicator of prognosis: A retrospective study in dogs with intervertebral disc disease and loss of deep pain perception [J].
Duval, J ;
Dewey, C ;
Roberts, R ;
Aron, D .
VETERINARY SURGERY, 1996, 25 (01) :6-12
[5]   Accuracy of the withdrawal reflex for localization of the site of cervical disk herniation in dogs: 35 cases (2004-2007) [J].
Forterre, Franck ;
Konar, Martin ;
Tomek, Ales ;
Doherr, Markus ;
Howard, Judith ;
Spreng, David ;
Vandevelde, Marc ;
Jaggy, Andre .
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 2008, 232 (04) :559-563
[9]   The Long-Term Effects of Mild to Moderate Hypothermia on Gray and White Matter Injury After Spinal Cord Ischemia in Rats [J].
Horiuchi, Toshinori ;
Kawaguchi, Masahiko ;
Kurita, Naoko ;
Inoue, Satoki ;
Nakamura, Mitsutoshi ;
Konishi, Noboru ;
Furuya, Hitoshi .
ANESTHESIA AND ANALGESIA, 2009, 109 (02) :559-566
[10]   Prognostic value of magnetic resonance imaging in dogs with paraplegia caused by thoracolumbar intervertebral disk extrusion: 77 cases (2000-2003) [J].
Ito, D ;
Matsunaga, S ;
Jeffery, ND ;
Sasaki, N ;
Nishimura, R ;
Mochizuki, M ;
Kasahara, M ;
Fujiwara, R ;
Ogawa, H .
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 2005, 227 (09) :1454-1460