Autoimnriunity in Primary Antibody Deficiencies

被引：48

作者：

Azizi, Gholamreza ^{[1
,5
]}

Ahmadi, Moslem ^{[6
]}

Abolhassani, Hassan ^{[5
,9
,10
]}

Yazdani, Reza ^{[2
,3
]}

Mohammadi, Hamed ^{[4
]}

Mirshafiey, Abbas ^{[5
,6
]}

Rezaei, Nima ^{[5
,7
,11
]}

Aghamohammadi, Asghar ^{[5
,8
]}

机构：

[1] Alborz Univ Med Sci, Imam Hassan Mojtaba Hosp, Dept Lab Med, Karaj, Iran

[2] Isfahan Univ Med Sci, Sch Med, Dept Immunol, Esfahan, Iran

[3] USERN, MIIG, Esfahan, Iran

[4] Tabriz Univ Med Sci, Sch Med, Dept Immunol, Tabriz, Iran

[5] Childrens Med Ctr Hosp, Pediat Ctr Excellence, Res Ctr Immunodeficiencies, Tehran, Iran

[6] Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran

[7] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[8] USERN, Primary Immunodeficiency Dis Network PIDNet, Tehran, Iran

[9] Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Lab Med, Div Clin Immunol, Stockholm, Sweden

[10] USERN, Primary Immunodeficiency Dis Network PIDNet, Stockholm, Sweden

[11] USERN, NIIMA, Boston, MA USA

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2016年 / 171卷 / 3-4期

关键词：

Primary antibody deficiencies; Autoimmunity; Antibody; Autoimmune hemolytic anemia; Immune thrombocytopenic purpura; COMMON VARIABLE IMMUNODEFICIENCY; X-LINKED AGAMMAGLOBULINEMIA; SELECTIVE IGA DEFICIENCY; REGULATORY T-CELLS; LOSS-OF-FUNCTION; MEMORY B-CELLS; IMMUNE-DEFICIENCY; AUTOIMMUNITY LESSONS; MOLECULAR-MECHANISMS; CVID PATIENTS;

D O I：

10.1159/000453263

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Primary antibody deficiencies (PADs) are the most common inherited primary immunodeficiencies in humans, characterized by hypogammaglobulinemia, an inability to produce specific antibodies, and recurrent infections mainly caused by encapsulated bacteria. However, it has been shown that inflammatory disorders, granulomatous lesions, lymphoproliferative diseases, cancer, and autoimnnunity are associated with the various types of PAD. Both systemic and organ-specific autoimmune diseases could be attributed to B-cell defects in PAD patients. Immune thrombocytopenic purpura and autoimmune hemolytic anemia are the most common autoimmune disorders in this group of patients. The aim of this review is to describe the proposed mechanisms for autoimmunity and to review the literature with respect to the reported autoimmune disorders in each type of PAD. (C) 2016 S. Karger AG, Basel

引用

页码：180 / 193

页数：14

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