Iridium( I)-Catalyzed Direct C-H Bond Alkylation of the C-7 Position of Indolines with Alkenes

被引：85

作者：

Pan, Shiguang ^{[1
]}

Ryu, Naoto ^{[1
]}

Shibata, Takanori ^{[1
,2
]}

机构：

[1] Waseda Univ, Sch Adv Sci & Engn, Dept Chem & Biochem, Shinjuku Ku, Tokyo 1698555, Japan

[2] ACT C, JST, Kawaguchi, Saitama 3320012, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2014年 / 356卷 / 05期

关键词：

alkenes; alkylation; CH functionalization; iridium catalysts; N-substituted indolines; REVERSIBLE ALPHA-ELIMINATION; SELECTIVE SYNTHESIS; INDOLES; ACTIVATION; FUNCTIONALIZATION; ARYLATION; NITROGEN; MECHANISM; ALKENYLATION; 2-ALKYLATION;

D O I：

10.1002/adsc.201300917

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A cationic iridium-catalyzed C-7 alkylation of N-substituted indoline derivatives with various alkenes has been developed. A variety of 7-alkylindolines were obtained in moderate to high yields. This protocol relies on the use of the carbonyl group on the nitrogen atom of indoline as a directing group and it is potentially applicable to the large-scale synthesis of 7-alkylindoles.

引用

页码：929 / 933

页数：5

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