The SWISS-MODEL Repository and associated resources

被引：513

作者：

Kiefer, Florian ^{[1
,2
]}

Arnold, Konstantin ^{[1
,2
]}

Kuenzli, Michael ^{[1
,2
]}

Bordoli, Lorenza ^{[1
,2
]}

Schwede, Torsten ^{[1
,2
]}

机构：

[1] Univ Basel, Biozentrum, Basel, Switzerland

[2] SIB Swiss Inst Bioinformat, Basel, Switzerland

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

基金：

美国国家卫生研究院;

关键词：

PROTEIN-STRUCTURE MODELS; THERMOTOGA-MARITIMA; HOMOLOGY; ENVIRONMENT; INHIBITOR; DISCOVERY; SELECTION; FAMILIES; DATABASE; BINDING;

D O I：

10.1093/nar/gkn750

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SWISS-MODEL Repository (http://swissmodel.expasy.org/repository/) is a database of 3D protein structure models generated by the SWISS-MODEL homology-modelling pipeline. The aim of the SWISS-MODEL Repository is to provide access to an up-to-date collection of annotated 3D protein models generated by automated homology modelling for all sequences in Swiss-Prot and for relevant models organisms. Regular updates ensure that target coverage is complete, that models are built using the most recent sequence and template structure databases, and that improvements in the underlying modelling pipeline are fully utilised. As of September 2008, the database contains 3.4 million entries for 2.7 million different protein sequences from the UniProt database. SWISS-MODEL Repository allows the users to assess the quality of the models in the database, search for alternative template structures, and to build models interactively via SWISS-MODEL Workspace (http://swissmodel.expasy.org/workspace/). Annotation of models with functional information and cross-linking with other databases such as the Protein Model Portal (http://www.proteinmodelportal.org) of the PSI Structural Genomics Knowledge Base facilitates the navigation between protein sequence and structure resources.

引用

页码：D387 / D392

页数：6

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