Drug-Delivery Systems of Green Tea Catechins for Improved Stability and Bioavailability

被引：36
作者：
Rodrigues, C. F. [1 ]
Ascencao, K. [1 ]
Silva, F. A. M. [1 ]
Sarmento, B. [1 ,2 ]
Oliveira, M. B. P. P. [3 ]
Andrade, J. C. [1 ]
机构：
[1] Inst Super Ciencias Saude Norte, CICS, P-4585116 Gandra Prd, Portugal
[2] Univ Porto, INEB Inst Engn Biomed, P-4150180 Oporto, Portugal
[3] Univ Porto, Fac Farm, REQUIMTE Dept Ciencias Quim, P-4050313 Oporto, Portugal
来源：
CURRENT MEDICINAL CHEMISTRY | 2013年 / 20卷 / 37期
关键词：
Antioxidant; drug delivery; epigallocatechin-3-gallate; green tea polyphenols; catechins; EGCG; NITRIC-OXIDE SYNTHASE; EPIGALLOCATECHIN GALLATE; IN-VITRO; (-)-EPIGALLOCATECHIN GALLATE; NANOPARTICLES ENHANCE; ORAL BIOAVAILABILITY; ANTIOXIDANT ACTIVITY; DIETARY POLYPHENOLS; GOLD NANOPARTICLES; PROSTATE-CANCER;
D O I：
10.2174/09298673113209990158
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Numerous studies in humans, animal models and cell lines have suggested the potential benefits from the consumption of green tea polyphenols, including prevention of cancer and heart diseases. However these potential effects have been strongly limited by green tea catechins low bioavailability, which hinders the development of therapeutic applications. In this review formulations that are being proposed for delivery of green tea catechins are discussed. New delivery systems are presented as valid alternatives to overcome the limitations such as green tea catechins poor stability or intestinal absorption.
引用
收藏
页码：4744 / 4757
页数：14
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