Drug-Delivery Systems of Green Tea Catechins for Improved Stability and Bioavailability

被引：36
作者：
Rodrigues, C. F. [1 ]
Ascencao, K. [1 ]
Silva, F. A. M. [1 ]
Sarmento, B. [1 ,2 ]
Oliveira, M. B. P. P. [3 ]
Andrade, J. C. [1 ]
机构：
[1] Inst Super Ciencias Saude Norte, CICS, P-4585116 Gandra Prd, Portugal
[2] Univ Porto, INEB Inst Engn Biomed, P-4150180 Oporto, Portugal
[3] Univ Porto, Fac Farm, REQUIMTE Dept Ciencias Quim, P-4050313 Oporto, Portugal
来源：
CURRENT MEDICINAL CHEMISTRY | 2013年 / 20卷 / 37期
关键词：
Antioxidant; drug delivery; epigallocatechin-3-gallate; green tea polyphenols; catechins; EGCG; NITRIC-OXIDE SYNTHASE; EPIGALLOCATECHIN GALLATE; IN-VITRO; (-)-EPIGALLOCATECHIN GALLATE; NANOPARTICLES ENHANCE; ORAL BIOAVAILABILITY; ANTIOXIDANT ACTIVITY; DIETARY POLYPHENOLS; GOLD NANOPARTICLES; PROSTATE-CANCER;
D O I：
10.2174/09298673113209990158
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Numerous studies in humans, animal models and cell lines have suggested the potential benefits from the consumption of green tea polyphenols, including prevention of cancer and heart diseases. However these potential effects have been strongly limited by green tea catechins low bioavailability, which hinders the development of therapeutic applications. In this review formulations that are being proposed for delivery of green tea catechins are discussed. New delivery systems are presented as valid alternatives to overcome the limitations such as green tea catechins poor stability or intestinal absorption.
引用
收藏
页码：4744 / 4757
页数：14
相关论文
共 146 条
[1]   Green tea averts age-dependent decline of hippocampal signaling systems related to antioxidant defenses and survival [J].
Assuncao, Marco ;
Santos-Marques, Maria J. ;
Carvalho, Felix ;
Andrade, Jose P. .
FREE RADICAL BIOLOGY AND MEDICINE, 2010, 48 (06) :831-838
[2]   A review on the use of cyclodextrins in foods [J].
Astray, G. ;
Gonzalez-Barreiro, C. ;
Mejuto, J. C. ;
Rial-Otero, R. ;
Simal-Gandara, J. .
FOOD HYDROCOLLOIDS, 2009, 23 (07) :1631-1640
[3]   Pharmacological profile of green tea and its polyphenols: a review [J].
Bansal, Sumit ;
Syan, Navneet ;
Mathur, Pooja ;
Choudhary, Shivani .
MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (11) :3347-3360
[4]   Formulation and characterization of polyphenol-loaded lipid nanocapsules [J].
Barras, A. ;
Mezzetti, A. ;
Richard, A. ;
Lazzaroni, S. ;
Roux, S. ;
Melnyk, P. ;
Betbeder, D. ;
Monfilliette-Dupont, N. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2009, 379 (02) :270-277
[5]   Effect of process unit operations and long-term storage on catechin contents in EGCG-enriched tea drink [J].
Bazinet, Laurent ;
Araya-Farias, Monica ;
Doyen, Alain ;
Trudel, Dominique ;
Tetu, Bernard .
FOOD RESEARCH INTERNATIONAL, 2010, 43 (06) :1692-1701
[6]   Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: A preliminary report from a one-year proof-of-principle study [J].
Bettuzzi, S ;
Brausi, M ;
Rizzi, F ;
Castagnetti, G ;
Peracchia, G ;
Corti, A .
CANCER RESEARCH, 2006, 66 (02) :1234-1240
[7]   EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity [J].
Bieschke, Jan ;
Russ, Jenny ;
Friedrich, Ralf P. ;
Ehrnhoefer, Dagmar E. ;
Wobst, Heike ;
Neugebauer, Katja ;
Wanker, Erich E. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (17) :7710-7715
[8]   Hepatotoxicity associated with supplements containing Chinese green tea (Camellia sinensis) [J].
Bonkovsky, HL .
ANNALS OF INTERNAL MEDICINE, 2006, 144 (01) :68-71
[9]   TLR4 Signaling Inhibitory Pathway Induced by Green Tea Polyphenol Epigallocatechin-3-Gallate through 67-kDa Laminin Receptor [J].
Byun, Eui Hong ;
Fujimura, Yoshinori ;
Yamada, Koji ;
Tachibana, Hirofumi .
JOURNAL OF IMMUNOLOGY, 2010, 185 (01) :33-45
[10]   Green tea polyphenol epigallocatechin-3-gallate inhibits TLR2 signaling induced by peptidoglycan through the polyphenol sensing molecule 67-kDa laminin receptor [J].
Byun, Eui-Hong ;
Omura, Toshinori ;
Yamada, Koji ;
Tachibana, Hirofumi .
FEBS LETTERS, 2011, 585 (05) :814-820
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