Regulation of TRPV5 and TRPV6 by associated proteins

被引：72

作者：

van de Graaf, SFJ ^{[1
]}

Hoenderop, JGJ ^{[1
]}

Bindels, RJM ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Nijmegen Med Ctr, Nijmegen Ctr Mol Life Sci, Dept Physiol, NL-6500 HB Nijmegen, Netherlands

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2006年 / 290卷 / 06期

关键词：

Rab11; calbindin; 80KH; BSPRY; Klotho; kidney;

D O I：

10.1152/ajprenal.00443.2005

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The epithelial Ca2+ channels TRPV5 and TRPV6 are the most Ca2+-selective members of the TRP channel superfamily. These channels are the prime target for hormonal control of the active Ca2+ flux from the urine space or intestinal lumen to the blood compartment. Insight into their regulation is, therefore, pivotal in our understanding of the (patho) physiology of Ca2+ homeostasis. The recent elucidation of TRPV5/6-associated proteins has provided new insight into the molecular mechanisms underlying the regulation of these channels. In this review, we describe the various means of TRPV5/6 regulation, the role of channel-associated proteins herein, and the relationship between both processes.

引用

页码：F1295 / F1302

页数：8

共 46 条

[1] The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease [J].

Abel, M ;

Hoenderop, J ;

Bindels, R .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2005, 371 (04) :295-306

[2] The epithelial calcium channels TRPV5 and TRPV6: regulation and implications for disease [J].

Monique van Abel ;

Joost G. J. Hoenderop ;

René J. M. Bindels .

Naunyn-Schmiedeberg's Archives of Pharmacology, 2005, 371 :295-306

[3] Human TRPV5 and TRPV6: Key players in cadmium and zinc toxicity [J].

Kovacs, Gergely ;

Montalbetti, Nicolas ;

Franz, Marie-Christine ;

Graeter, Stefanie ;

Simonin, Alexandre ;

Hediger, Matthias A. .

CELL CALCIUM, 2013, 54 (04) :276-286

[4] Concerted action of associated proteins in the regulation of TRPVS and TRPV6 [J].

Schoeber, J. P. H. ;

Hoenderop, J. G. J. ;

Bindels, R. J. M. .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2007, 35 :115-119

[5] The β-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6 [J].

Lu, Peng ;

Boros, Sandor ;

Chang, Qing ;

Bindels, Rene J. ;

Hoenderop, Joost G. .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2008, 23 (11) :3397-3402

[6] First evidence of TRPV5 and TRPV6 channels in human parathyroid glands: possible involvement in neoplastic transformation [J].

Giusti, Laura ;

Cetani, Filomena ;

Da Valle, Ylenia ;

Pardi, Elena ;

Ciregia, Federica ;

Donadio, Elena ;

Gargini, Claudia ;

Piano, Ilaria ;

Borsari, Simona ;

Jaber, Ali ;

Caputo, Antonella ;

Basolo, Fulvio ;

Giannaccini, Gino ;

Marcocci, Claudio ;

Lucacchini, Antonio .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2014, 18 (10) :1944-1952

[7] Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear [J].

Takumida, Masaya ;

Ishibashi, Takuya ;

Hamamoto, Takao ;

Hirakawa, Katsuhiro ;

Anniko, Matti .

ACTA OTO-LARYNGOLOGICA, 2009, 129 (12) :1340-1350

[8] Decreased Expression of the Epithelial Ca2+ Channel TRPV5 and TRPV6 in Human Renal Cell Carcinoma Associated With Vitamin D Receptor [J].

Wu, Yongyang ;

Miyamoto, Tatsuya ;

Li, Kai ;

Nakagomi, Hiroshi ;

Sawada, Norifumi ;

Kira, Satoru ;

Kobayashi, Hideki ;

Zakohji, Hidenori ;

Tsuchida, Takayuki ;

Fukazawa, Mizuya ;

Araki, Isao ;

Takeda, Masayuki .

JOURNAL OF UROLOGY, 2011, 186 (06) :2419-2425

[9] On the Role of Pore Helix in Regulation of TRPV5 by Extracellular Protons [J].

Byung-Il Yeh ;

Joonho Yoon ;

Chou-Long Huang .

The Journal of Membrane Biology, 2006, 212 :191-198

[10] On the role of pore helix in regulation of TRPV5 by extracellular protons [J].

Yeh, Byung-Il ;

Yoon, Joonho ;

Huang, Chou-Long .

JOURNAL OF MEMBRANE BIOLOGY, 2006, 212 (03) :191-198

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