Regulation of TRPV5 and TRPV6 by associated proteins

被引：72
作者：
van de Graaf, SFJ [1 ]
Hoenderop, JGJ [1 ]
Bindels, RJM [1 ]
机构：
[1] Radboud Univ Nijmegen, Nijmegen Med Ctr, Nijmegen Ctr Mol Life Sci, Dept Physiol, NL-6500 HB Nijmegen, Netherlands
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2006年 / 290卷 / 06期
关键词：
Rab11; calbindin; 80KH; BSPRY; Klotho; kidney;
D O I：
10.1152/ajprenal.00443.2005
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The epithelial Ca2+ channels TRPV5 and TRPV6 are the most Ca2+-selective members of the TRP channel superfamily. These channels are the prime target for hormonal control of the active Ca2+ flux from the urine space or intestinal lumen to the blood compartment. Insight into their regulation is, therefore, pivotal in our understanding of the (patho) physiology of Ca2+ homeostasis. The recent elucidation of TRPV5/6-associated proteins has provided new insight into the molecular mechanisms underlying the regulation of these channels. In this review, we describe the various means of TRPV5/6 regulation, the role of channel-associated proteins herein, and the relationship between both processes.
引用
收藏
页码：F1295 / F1302
页数：8
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