Admixture in Latin America

被引：69

作者：

Adhikari, Kaustubh ^{[1
]}

Mendoza-Revilla, Javier ^{[1
]}

Chacon-Duque, Juan Camilo ^{[1
]}

Fuentes-Guajardo, Macarena ^{[1
]}

Ruiz-Linares, Andres ^{[1
]}

机构：

[1] UCL, Dept Genet Evolut & Environm, London WC1E 6BT, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2016年 / 41卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; HUMAN GENETIC DIVERSITY; BREAST-CANCER; RISK LOCI; SEX BIAS; ANCESTRY; POPULATION; PATTERNS; PREVALENCE; SELECTION;

D O I：

10.1016/j.gde.2016.09.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Latin Americans arguably represent the largest recently admixed populations in the world. This reflects a history of massive settlement by immigrants (mostly Europeans and Africans) and their variable admixture with Natives, starting in 1492. This process resulted in the population of Latin America showing an extensive genetic and phenotypic diversity. Here we review how genetic analyses are being applied to examine the demographic history of this population, including patterns of mating, population structure and ancestry. The admixture history of Latin America, and the resulting extensive diversity of the region, represents a natural experiment offering an advantageous setting for genetic association studies. We review how recent analyses in Latin Americans are contributing to elucidating the genetic architecture of human complex traits.

引用

页码：106 / 114

页数：9

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