Effect on perceived control and psychological distress of genetic knowledge in women with breast cancer receiving a BRCA1/2 test result

被引：15

作者：

Bredart, Anne ^{[1
,2
]}

Kop, Jean-Luc ^{[3
]}

De Pauw, Antoine ^{[4
]}

Caron, Olivier ^{[5
]}

Fajac, Anne ^{[6
]}

Nogues, Catherine ^{[7
]}

Stoppa-Lyonnet, Dominique ^{[4
]}

Dolbeault, Sylvie ^{[1
,8
]}

机构：

[1] Inst Curie, Support Care Dept, Psychooncol Unit, 26 Rue Ulm, F-75005 Paris 05, France

[2] Univ Paris 05, 71 Ave Edouard Vaillant, F-92774 Boulogne, France

[3] Univ Lorraine, Inter Psy, 3 Pl Godefroy de Bouillon,BP 33 97, F-54015 Nancy, France

[4] Inst Curie, Canc Genet Clin, 26 Rue Ulm, F-75005 Paris 05, France

[5] Gustave Roussy Hop Univ, Canc Genet Clin, 114 Rue Ed Vaillant, F-94805 Villejuif, France

[6] ER2 UPMC Univ Pierre & Marie Curie, Hop Tenon, AP HP, Serv Histol Biol, 4 Rue Chine, F-75020 Paris, France

[7] Inst Paoli Calmettes, 232 Blvd St Margueritte, Marseille, France

[8] Univ Paris Sud, Univ Paris Saclay, CESP, UVSQ,INSERM, Villejuif, France

来源：

BREAST | 2017年 / 31卷

关键词：

Genetic knowledge; Breast cancer; BRCA1/2; counseling; Distress; Cancer risk perception; HEREDITARY BREAST; RISK PERCEPTION; OVARIAN-CANCER; CONTROLLED-TRIAL; IMPACT; INFORMATION; ADJUSTMENT; VARIANTS; OUTCOMES; SCALE;

D O I：

10.1016/j.breast.2016.10.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Information provision during BRCA1/2 genetic counseling is complex and expected to be increasingly so with gene panel testing. This prospective study evaluated whether genetic knowledge in counselees with breast cancer (BC) after a pre-test genetic counseling visit (T1) enhance their feeling of personal control while minimizing distress after the notification of BRCA1/2 result (T2). At T1, 243 (89% response rate) counselees completed questionnaires on genetic knowledge (BGKQ), perceived cancer genetic risk; of which, at T2, 180 (66%) completed the BGKQ again, scales of anxiety/depression, distress specific to genetic risk, and perceived control. Multilevel models were performed accounting for clinician, and testing an effect of knowledge on psychological outcomes according to the adequacy of counselees' perceived genetic predisposition to cancer. The mean knowledge score was moderate at T1, decreased while not significantly differing by BRCA1/2 test result at T2. Knowledge at T1 had no direct effect on psychological outcomes, but in counselees who over-estimated their cancer genetic risk, higher knowledge at T1 predicted higher specific distress at T2. In BC affected counselees who over-estimate their cancer genetic risk, higher BRCA1/2 pre-test genetic knowledge seem to lead to increased specific distress. Identifying these BC affected counselees who overestimate their genetic cancer risk and helping them to interpret their genetic knowledge instead of providing them with exhaustive genetic information could minimize their distress after test result receipt. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：121 / 127

页数：7

共 48 条

[1] Counselees' Expressed Level of Understanding of the Risk Estimate and Surveillance Recommendation are Not Associated with Breast Cancer Surveillance Adherence [J].